Relationship between media-to-lumen ratio of subcutaneous small arteries and wall-to-lumen ratio of retinal arterioles evaluated noninvasively by scanning laser Doppler flowmetry
Relationship between media-to-lumen ratio of subcutaneous small arteries and wall-to-lumen ratio of retinal arterioles evaluated noninvasively by scanning laser Doppler flowmetry
复制标题
扫描激光多普勒血流计无创评估皮下小动脉中管腔比与视网膜小动脉壁管腔比的关系
DOI：
10.1097/hjh.0b013e328352f81d
复制
发表时间：
2012
影响因子：
4.9
通讯作者：
E. Rosei
中科院分区：
文献类型：
--
作者：
D. Rizzoni;E. Porteri;S. Duse;C. de Ciuceis;C. A. Rosei;E. La Boria;F. Semeraro;C. Costagliola;A. Sebastiani;P. Danzi;G. Tiberio;S. Giulini;F. Docchio;G. Sansoni;A. Sarkar;E. Rosei
背景资料：皮下小阻力动脉的结构改变，如增加的中膜-管腔比所示，经常存在于高血压和/或糖尿病患者中，并且可能代表观察到的最早改变。此外，通过显微肌描记术评估的小动脉中腔比具有很强的预后意义;然而，由于需要皮下脂肪活检，因此其广泛的评估受到评估侵入性的限制。最近，采用扫描激光多普勒血流仪（SLDF）对视网膜小动脉的壁腔进行了无创测量。然而，这项新技术尚未与通常被认为是金标准方法的微肌描记术测量进行比较。方法和结果：我们调查了40名个人和病人，其中24名高血压患者和16名正常血压者。所有患者在择期手术期间均接受了皮下脂肪活检。解剖皮下小阻力动脉，并安装在钢丝肌描记器上，测量中膜-管腔比。此外，通过SLDF（Heidelberg Retina Flowmeter，Heidelberg Engineering）进行视网膜小动脉的壁腔比的评价。皮下小动脉中腔比与视网膜小动脉壁腔比呈显著正相关（r = 0.76，P <0.001; r ~ 2 = 0.57）。 结论：一种无创且易于重复的方法（观察者内和观察者间变异系数<13%），例如通过SLDF评估眼底小动脉，与皮下小动脉中膜-管腔比的有创、准确和解剖学相关的显微肌描记术测量相比，可以提供类似的微血管形态学信息。
Background: Structural alterations of subcutaneous small resistance arteries, as indicated by an increased media-to-lumen ratio, are frequently present in hypertensive and/or diabetic patients, and may represent the earliest alteration observed. Furthermore, media-to-lumen ratio of small arteries evaluated by micromyography has a strong prognostic significance; however, its extensive evaluation is limited by the invasivity of the assessment, since a biopsy of subcutaneous fat is needed. Noninvasive measurement of wall-to-lumen of retinal arterioles using scanning laser Doppler flowmetry (SLDF) has recently been introduced. However, this new technique has not yet been compared to micromyographic measurement, generally considered the gold standard approach. Methods and results: We investigated 40 individuals and patients, 24 of them were hypertensive patients and 16 normotensive individuals. All patients underwent a biopsy of subcutaneous fat during an elective surgical intervention. Subcutaneous small resistance arteries were dissected and mounted on a wire myograph, and media-to-lumen ratio was measured. In addition, an evaluation of wall-to-lumen ratio of retinal arterioles by SLDF was performed (Heidelberg Retina Flowmeter, Heidelberg Engineering). A close correlation was observed between media-to-lumen ratio of subcutaneous small arteries and wall-to-lumen ratio of retinal arterioles (r = 0.76, P < 0.001; P < 0.001, r2 = 0.57). Conclusion: A noninvasive and easily repeatable procedure (intraobserver and interobserver variation coefficient <13%) such as an evaluation of the arterioles in the fundus oculi by SLDF may provide similar information regarding microvascular morphology compared with an invasive, accurate and prognostically relevant micromyographic measurement of media-to-lumen ratio of subcutaneous small arteries.
影响因子：
120.7
作者：
Wong, TY;Klein, R;Hubbard, LD
通讯作者：
Hubbard, LD