Rhodium Catalyzed Cyanation of Chelation Assisted C-H Bonds
Rhodium Catalyzed Cyanation of Chelation Assisted C-H Bonds
复制标题
DOI：
10.1021/ol402201c
复制
发表时间：
2013-10-04
期刊：
影响因子：
5.2
通讯作者：
Anbarasan, Pazhamalai
中科院分区：
文献类型：
--
作者：
Chaitanya, Manthena;Yadagiri, Dongari;Anbarasan, Pazhamalai
描述了使用 N-氰基-N-苯基-对甲基苯磺酰胺作为有效的氰化试剂，进行铑催化的螯合辅助 C-H 键的氰化。本方法能够以良好至优异的产率合成各种苯甲腈衍生物。许多螯合基团对于目前的 C-H 键氰化也是有效的。此外，所开发的方法还应用于异喹啉生物碱甲尼泊啡的正式合成。
A rhodium-catalyzed cyanation of chelation assisted C-H bonds is described employing N-cyano-N-phenyl-p-methylbenzenesulfonamide as an efficient cyanating reagent. The present method allowed the synthesis of various benzonitirle derivatives in good to excellent yield. A number of chelating groups are also effective in the present cyanation of C-H bonds. In addition, the developed methodology was applied in the formal synthesis of the isoquinoline alkaloid, menisporphine.