B cells responses and cytokine production are regulated by their immune microenvironment.
B cells responses and cytokine production are regulated by their immune microenvironment.
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DOI：
10.1016/j.cyto.2015.02.007
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发表时间：
2015-08
期刊：
影响因子：
3.8
通讯作者：
Zlotnik A
中科院分区：
文献类型：
--
作者：
Vazquez MI;Catalan-Dibene J;Zlotnik A
适应性免疫系统由两种类型的淋巴细胞组成：T细胞和B细胞。这两种淋巴细胞起源于共同的前体，但根本不同，B细胞介导体液免疫，而T细胞介导细胞介导免疫。在细胞因子产生中，初始T细胞在活化后产生多种细胞因子，而初始活化的B细胞不产生。B细胞能够产生细胞因子，但它们的细胞因子产生取决于它们的分化状态和活化条件。因此，与活化后可产生大量细胞因子的T细胞不同，B细胞需要特定的分化和活化条件来产生细胞因子。许多细胞因子也作用于B细胞。在此，我们讨论了几种细胞因子及其对B细胞的作用，包括：白细胞介素，IL-7，IL-4，IL-6，IL-10和干扰素，IFN-α，IFN-β，IFN-γ。这些细胞因子在B细胞的发育、存活、分化和/或增殖中起重要作用。某些趋化因子在B细胞功能，即抗体产生中也起重要作用。作为一个例子，我们讨论了CCL 28，趋化因子，指导浆细胞迁移到粘膜网站。最后，我们简要概述了B细胞作为细胞因子的生产者和他们可能的功能性后果的免疫反应。
The adaptive immune system consists of two types of lymphocytes: T and B cells. These two lymphocytes originate from a common precursor, yet are fundamentally different with B cells mediating humoral immunity while T cells mediate cell mediated immunity. In cytokine production, naïve T cells produce multiple cytokines upon activation while naïve activated B cells do not. B cells are capable of producing cytokines, but their cytokine production depends on their differentiation state and activation conditions. Hence, unlike T cells that can produce a large amount of cytokines upon activation, B cells require specific differentiation and activation conditions to produce cytokines. Many cytokines act on B cells as well. Here, we discuss several cytokines and their effects on B cells including: Interleukins, IL-7, IL-4, IL-6, IL-10, and Interferons, IFN-α, IFN-β, IFN-γ. These cytokines play important roles in the development, survival, differentiation and/or proliferation of B cells. Certain chemokines also play important roles in B cell function, namely antibody production. As an example, we discuss CCL28, a chemokine that directs the migration of plasma cells to mucosal sites. We conclude with a brief overview of B cells as cytokine producers and their likely functional consequences on the immune response.
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影响因子：
32.4
作者：
Alugupalli, KR;Leong, JM;Gerstein, RM
通讯作者：
Gerstein, RM
影响因子：
9.3
作者：
Beurel E;Jope RS
通讯作者：
Jope RS
影响因子：
5.4
作者：
Cantin, E;Tanamachi, B;Openshaw, H
通讯作者：
Openshaw, H
DOI：
10.1038/nri3383
发表时间：
2013-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.3
作者：
ABED, NS;CHACE, JH;COWDERY, JS
通讯作者：
COWDERY, JS