Maternal immunization against viral disease
Maternal immunization against viral disease
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DOI：
10.1016/s0264-410x(98)00108-x
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发表时间：
1998-08-01
期刊：
影响因子：
5.5
通讯作者：
Piedra, PA
中科院分区：
文献类型：
--
作者：
Englund, J;Glezen, WP;Piedra, PA
母源抗体对许多病毒性疾病的保护作用已被公认。使用产妇免疫被认为是一种手段，以加强这种保护，在年幼的婴儿对疾病。母亲免疫接种的优点包括以下事实：幼儿最容易感染，但对疫苗的反应最低;孕妇可获得医疗护理，对疫苗的反应良好; IgG抗体在妊娠晚期可以很好地穿过胎盘;孕妇免疫接种有可能使母亲和婴儿受益。缺点包括潜在的抑制婴儿对主动免疫或自然感染的反应，以及制药公司和医生的责任问题。已经描述了用脊髓灰质炎病毒、流感病毒和风疹的病毒疫苗对孕妇进行免疫接种，并且已经发现用这些疫苗对母亲和胎儿都是安全的。对用纯化的RSV融合蛋白免疫的产后妇女的开放标签研究（PFP-2 Wyeth-Lederle Pediatrics and Vaccines，Inc.，Pearl River，NY）证明该疫苗无反应原性和免疫原性;在母乳中检测到RSV特异性抗体。可以考虑对孕妇接种纯化蛋白或亚单位疫苗，以对抗新生儿病毒病原体，如呼吸道合胞病毒、副流感病毒、疱疹病毒群和人类免疫缺陷病毒。需要进一步研究以确定孕产妇免疫接种的安全性和有效性。(C)1998 Elsevier Science Ltd保留所有权利。
The protective effect of maternal antibody against many viral diseases has been recognized. The use of maternal immunization has been considered as a means to augment this protection in the young infant against disease. Advantages of maternal immunization include the fact that young infants are most susceptible to infections but least responsive to vaccines, that pregnant women are accessible to medical care and respond well to vaccines, that IgG antibodies cross the placenta well during the third trimester; and that immunization of the pregnant woman has the potential to benefit both the mother and the infant. Disadvantages include the potential inhibition of an infant's response to active in immunization or natural infection and liability issues with pharmaceutical companies and physicians. Immunization of pregnant women with viral vaccines for poliovirus, influenza viruses, and rubella has been described and maternal vaccination with these vaccines has been found to be safe for both the mother and the fetus. An open-label study of post-partum women immunized with the purified fusion protein of RSV (PFP-2 Wyeth-Lederle Pediatrics and Vaccines, Inc., Pearl River, NY) demonstrated that the vaccine was non-reactogenic and immunogenic; RSV-specific antibody was detected in breast milk. Immunization of pregnant women with purified protein or subunit vaccines could be considered against neonatal viral pathogens, such as respiratory syncytial virus, parainfluenza viruses, herpes group viruses, and human immunodeficiency virus. Further studies are needed to define the safety and efficacy of maternal immunization. (C) 1998 Elsevier Science Ltd All rights reserved.