LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1
LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1
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DOI：
10.1038/nn779
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发表时间：
2002-01-01
影响因子：
25
通讯作者：
Browning, MD
中科院分区：
文献类型：
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作者：
Grosshans, DR;Clayton, DA;Browning, MD
在大鼠海马CA1区，长期增强（LTP）需要激活NMDA受体（NMDARs）并导致AMPA受体（AMPAR）功能增强。在新生儿海马体中，突触强度的增加似乎是通过向突触传递ampar介导的。在此，我们研究了LTP诱导成年大鼠脑中天然AMPA和NMDA受体表面表达的变化。与出生后早期大鼠相比，我们发现成年大鼠的LTP不会改变ampar的膜关联。相反，LTP以PKC和src家族依赖的方式导致NM dar的快速表面表达。目前的研究表明，ltp依赖性AMPA受体的运输发生了发育转变。此外，我们的研究结果表明，NMDA受体的插入可能是调节突触可塑性的关键步骤。
In the CA1 region of the rat hippocampus, long-term potentiation (LTP) requires the activation of NMDA receptors (NMDARs) and leads to an enhancement of AMPA receptor (AMPAR) function. In neonatal hippocampus, this increase in synaptic strength seems to be mediated by delivery of AMPARs to the synapse. Here we studied changes in surface expression of native AMPA and NMDA receptors following induction of LTP in the adult rat brain. In contrast to early postnatal rats, we find that LTP in the adult rat does not alter membrane association of AMPARs. Instead, LTP leads to rapid surface expression of NM DARs in a PKC- and Src-family-dependent manner. The present study suggests a developmental shift in the LTP-dependent trafficking of AMPA receptors. Moreover, our results indicate that insertion of NMDA receptors may be a key step in regulating synaptic plasticity.