Moonshots for aging.
Moonshots for aging.
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衰老的月经。
DOI：
10.3233/nha-190064
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发表时间：
2020-11-03
影响因子：
--
通讯作者：
Peterson TR
中科院分区：
文献类型：
--
作者：
Kumar S;Peterson TR
随着全球人口老龄化，人们对长寿和提高晚年生活质量的兴趣与日俱增。然而，研究衰老--身体机能的衰退--既昂贵又耗时。尽管研究成功地让模型生物活得更长，但仍然没有任何真正可行的解决方案来延缓人类的衰老。在太空旅行中，科学家和工程师无法知道登上月球需要做些什么。他们不得不从理论和较短距离的测试中进行推断。也许随着年龄的增长，我们需要类似的登月哲学。尽管“枪击”可能意味着医学，但也许我们需要考虑的不仅仅是医学干预。就像曾经的月亮一样，我们似乎离增加人类健康寿命(一个人的健康时期)或寿命(一个人的寿命)的可证实疗法还有很长一段路要走。因此，这项审查的重点是激进的建议。我们希望这能激发关于我们可以考虑采取与正在进行的衰老研究有显著不同的做法的讨论。
As the global population ages, there is increased interest in living longer and improving one’s quality of life in later years. However, studying aging – the decline in body function – is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren’t really any feasible solutions for delaying aging in humans. With space travel, scientists and engineers couldn’t know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though “shot” might imply medicine, perhaps we need to think beyond medical interventions. Like the moon once was, we seem a long way away from provable therapies to increase human healthspan (the healthy period of one’s life) or lifespan (how long one lives). This review therefore focuses on radical proposals. We hope it might stimulate discussion on what we might consider doing significantly differently than ongoing aging research.