The Future of Precision Medicine to Predict Outcomes and Control Tissue Remodeling in Inflammatory Bowel Disease.
The Future of Precision Medicine to Predict Outcomes and Control Tissue Remodeling in Inflammatory Bowel Disease.
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DOI：
10.1053/j.gastro.2021.09.077
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发表时间：
2022-04
期刊：
影响因子：
29.4
通讯作者：
Rieder F
中科院分区：
文献类型：
--
作者：
Lamb CA;Saifuddin A;Powell N;Rieder F
炎症性肠病的特征是显著的个体间异质性。随着药理学和非药理学干预措施的广泛选择以及处于高级发展阶段，未来十年的优先事项是确定预测治疗反应和病程的准确方法。精准医疗战略将允许根据个体患者的需求定制预防和治疗决策。在这篇综述中，我们考虑了炎症性肠病精准医学的未来。我们讨论了从专注于短期症状反应的研究扩展到综合多组学系统生物学策略以识别和验证支持精确方法的生物标志物的迫切需要。至关重要的是，国际社会有集体责任为科学发现和验证提供良好的表型和策划的纵向数据集。研究还必须研究免疫反应的更广泛方面，包括细胞外基质的成分，以更好地了解引发和维持组织纤维化和长期疾病并发症的生物途径。
Inflammatory bowel disease is characterised by significant interindividual heterogeneity. With a wider selection of pharmacological and non-pharmacological interventions available and in advanced developmental stages, a priority for the coming decade is to determine accurate methods of predicting treatment response and disease course. Precision medicine strategies will allow tailoring of preventative and therapeutic decisions to individual patient needs. In this review, we consider the future of precision medicine in inflammatory bowel disease. We discuss the critical need to extend from research focussed on short-term symptomatic response, to integrative multi-omic systems biology strategies to identify and validate biomarkers that underpin precision approaches. Crucially, the international community has collective responsibility to provide well-phenotyped and curated, longitudinal datasets for scientific discovery and validation. Research must also study broader aspects of the immune response including components of the extracellular matrix to better understand biological pathways initiating and perpetuating tissue fibrosis and longer-term disease complications.
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影响因子：
7.6
作者：
Blesl A;Binder L;Högenauer C;Wenzl H;Borenich A;Pregartner G;Berghold A;Mestel S;Kump P;Baumann-Durchschein F;Petritsch W
通讯作者：
Petritsch W
DOI：
10.1016/j.cgh.2018.09.008
发表时间：
2019-08
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Ballengee CR;Stidham RW;Liu C;Kim MO;Prince J;Mondal K;Baldassano R;Dubinsky M;Markowitz J;Leleiko N;Hyams J;Denson L;Kugathasan S
通讯作者：
Kugathasan S
影响因子：
7.6
作者：
Ansari, A.;Arenas, M.;Sanderson, J.
通讯作者：
Sanderson, J.
影响因子：
24.5
作者：
Bernstein, Charles N.;Loftus, Edward V., Jr.;Moum, Bjorn
通讯作者：
Moum, Bjorn
影响因子：
24.5
作者：
Aschenbrenner D;Quaranta M;Banerjee S;Ilott N;Jansen J;Steere B;Chen YH;Ho S;Cox K;Arancibia-Cárcamo CV;Coles M;Gaffney E;Travis SP;Denson L;Kugathasan S;Schmitz J;Powrie F;Sansom SN;Uhlig HH
通讯作者：
Uhlig HH