Engineered Enzymes and Bioinspired Catalysts for Energy Conversion
Engineered Enzymes and Bioinspired Catalysts for Energy Conversion
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DOI：
10.1021/acsenergylett.9b01308
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发表时间：
2019-08
影响因子：
22
通讯作者：
Jennifer Le;K. Bren
中科院分区：
文献类型：
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作者：
Jennifer Le;K. Bren
金属酶通过催化氧化还原反应在生态地球化学循环中发挥重要作用。这些生物催化剂的结构-功能关系的阐明为开发用于燃料生产和小分子活化的生物启发催化剂提供了基础。在这个角度来看，我们强调了工程生物分子和生物启发催化剂的发展，用于还原H+，O2和CO2以及H2和H2O的氧化。质子转移和第二层相互作用的作用，特别是突出。
Metalloenzymes play critical roles in the environment by catalyzing redox reactions in biogeochemical cycles. The elucidation of structure–function relationships in these biocatalysts has provided a foundation for the development of bioinspired catalysts for fuel production and small-molecule activation. In this Perspective, we highlight developments in engineered biomolecular and bioinspired catalysts for the reduction of H+, O2, and CO2 and for the oxidation of H2 and H2O. The roles of proton transfers and second-sphere interactions in particular are highlighted.