Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women: Protocol for a Pilot Study.
Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women: Protocol for a Pilot Study.
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DOI：
10.2196/29191
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发表时间：
2021-07-22
影响因子：
1.7
通讯作者：
Powell-Wiley TM
中科院分区：
文献类型：
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作者：
Tamura K;Curlin K;Neally SJ;Vijayakumar NP;Mitchell VM;Collins BS;Gutierrez-Huerta C;Troendle JF;Baumer Y;Osei Baah F;Turner BS;Gray V;Tirado BA;Ortiz-Chaparro E;Berrigan D;Mehta NN;Vaccarino V;Zenk SN;Powell-Wiley TM
创新的心血管（CV）风险标志物和健康行为与邻里压力源的分析是必不可少的，以进一步阐明不良邻里社会条件导致不良CV结果的机制。我们建议客观地测量身体活动（PA），久坐不动的行为，并通过智能手机应用程序使用加速度计，GPS和实时感知的生态瞬时评估邻里压力，并将这些与白色和非洲裔美国妇女在华盛顿，DC，社区的样本中的生物措施。本研究的主要目的是检验一个假设，即生活在不利的社区社会条件与较高的压力相关的神经活动之间的60名健康妇女生活在高或低社会经济地位的社区在华盛顿，DC。本研究的子目标1是检验使用加速度计客观测量的PA调节该关联的假设。第二个目的是检验居住在不利的社区社会环境条件与血管功能差异有关的假设。本研究的子目标2是检验这一假设，即客观测量的PA调节了这种关联。本研究的第三个目的是检验这一假设，即不利的邻里社会环境条件与免疫系统激活的差异有关。拟定的研究将是横断面研究，样本至少包括来自华盛顿3号和5号病房的60名女性（30名健康白色女性和30名健康黑人女性）。妇女样本（n=30）将从3号病房的高收入地区招募，来自3号病房家庭收入中位数范围15%以内的人口普查区。其他参与者（n=30）将从5号病房的低收入地区招募，这些地区来自5号病房家庭收入中位数范围内15%的人口普查区。最后，来自3号病房和5号病房的参与者将根据年龄、种族和BMI进行匹配。参与者将佩戴GPS装置和加速计，并使用智能手机真实的实时报告他们的压力和情绪。然后，我们将研究GPS衍生的邻域变量，压力相关的神经活动措施，和不良生物标志物之间的关联。美国国立卫生研究院机构审查委员会已经批准了这项研究。招募工作将于2021年夏季开始。这项研究的结果可以为多层次行为干预和政策的制定提供信息，以更好地管理促进免疫系统激活或心理社会压力的环境因素，同时努力增加PA，从而影响CV健康。PRR1-10.2196/29191
Innovative analyses of cardiovascular (CV) risk markers and health behaviors linked to neighborhood stressors are essential to further elucidate the mechanisms by which adverse neighborhood social conditions lead to poor CV outcomes. We propose to objectively measure physical activity (PA), sedentary behavior, and neighborhood stress using accelerometers, GPS, and real-time perceived ecological momentary assessment via smartphone apps and to link these to biological measures in a sample of White and African American women in Washington, DC, neighborhoods. The primary aim of this study is to test the hypothesis that living in adverse neighborhood social conditions is associated with higher stress-related neural activity among 60 healthy women living in high or low socioeconomic status neighborhoods in Washington, DC. Sub-aim 1 of this study is to test the hypothesis that the association is moderated by objectively measured PA using an accelerometer. A secondary objective is to test the hypothesis that residing in adverse neighborhood social environment conditions is related to differences in vascular function. Sub-aim 2 of this study is to test the hypothesis that the association is moderated by objectively measured PA. The third aim of this study is to test the hypothesis that adverse neighborhood social environment conditions are related to differences in immune system activation. The proposed study will be cross-sectional, with a sample of at least 60 women (30 healthy White women and 30 healthy Black women) from Wards 3 and 5 in Washington, DC. A sample of the women (n=30) will be recruited from high-income areas in Ward 3 from census tracts within a 15% of Ward 3’s range for median household income. The other participants (n=30) will be recruited from low-income areas in Wards 5 from census tracts within a 15% of Ward 5’s range for median household income. Finally, participants from Wards 3 and 5 will be matched based on age, race, and BMI. Participants will wear a GPS unit and accelerometer and report their stress and mood in real time using a smartphone. We will then examine the associations between GPS-derived neighborhood variables, stress-related neural activity measures, and adverse biological markers. The National Institutes of Health Institutional Review Board has approved this study. Recruitment will begin in the summer of 2021. Findings from this research could inform the development of multilevel behavioral interventions and policies to better manage environmental factors that promote immune system activation or psychosocial stress while concurrently working to increase PA, thereby influencing CV health. PRR1-10.2196/29191
DOI：
10.1016/j.ssmph.2021.100760
发表时间：
2021-03
期刊：
SSM - population health
影响因子：
--
作者：
Tamura K;Orstad SL;Cromley EK;Neally SJ;Claudel SE;Andrews MR;Ceasar J;Sims M;Powell-Wiley TM
通讯作者：
Powell-Wiley TM