Preterm delivery in women with pregestational diabetes mellitus or chronic hypertension relative to women with uncomplicated pregnancies
Preterm delivery in women with pregestational diabetes mellitus or chronic hypertension relative to women with uncomplicated pregnancies
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DOI：
10.1067/mob.2000.107621
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发表时间：
2000-12-01
影响因子：
9.8
通讯作者：
Roberts, J
中科院分区：
文献类型：
--
作者：
Sibai, BM;Caritis, SN;Roberts, J
目的：本研究的目的是比较慢性高血压或妊娠期糖尿病妇女的指示早产率和自然早产率与健康妇女的早产率。研究设计：对参加前瞻性观察研究预测早产的健康单胎妊娠妇女(对照组，n=2738)、妊娠期糖尿病需要胰岛素治疗的妇女(n=461)和慢性高血压妇女(n=761)的数据进行二次分析。后两组参加了一项预防先兆子痫的随机多中心试验。主要观察指标是自然早产率(早产或胎膜破裂)或有指征的早产率(母体或胎儿原因)，以及新生儿结局。结果：糖尿病和高血压妇女的总早产率(38%)显著高于对照组(13.9%)。送货率也明显高于
OBJECTIVE: The purpose of this study was to compare the rates of indicated and spontaneous preterm delivery among women with chronic hypertension or pregestational diabetes mellitus with the rates among healthy women.STUDY DESIGN: This was a secondary analysis of data from healthy women with singleton gestations enrolled in a prospective observational study for prediction of preterm delivery (control group, n = 2738), women-with pregestational diabetes mellitus requiring insulin therapy (n = 461), and women with chronic hypertension (n = 761). The two latter groups were enrolled in a randomized multicenter trial for prevention of preeclampsia. The main outcome measures were rates of preterm delivery, either spontaneous (preterm labor or rupture of membranes) or indicated (for maternal or fetal reasons), and neonatal outcomes.RESULTS: The overall rates of preterm delivery were significantly higher among women with diabetes mellitus (38%) and hypertension (33.1%) than among control women (13.9%). Rates were also significantly higher for delivery at