Modulation of protein release from biodegradable core-shell structured fibers prepared by coaxial electrospinning
Modulation of protein release from biodegradable core-shell structured fibers prepared by coaxial electrospinning
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DOI：
10.1002/jbm.b.30510
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发表时间：
2006-10-01
影响因子：
3.4
通讯作者：
Zhu, Kangjie
中科院分区：
文献类型：
--
作者：
Jiang, Hongliang;Hu, Yingqian;Zhu, Kangjie
以聚（ε - 己内酯）为壳，含牛血清白蛋白（BSA）的葡聚糖为核，通过同轴静电纺丝制备了可生物降解的核 - 壳结构纤维，用于蛋白质的包埋和控释。纤维中BSA的负载百分比及其释放速率可通过静电纺丝过程中内层纺丝液的进料速率方便地改变。随着内层纺丝液进料速率的增加，BSA的负载百分比增加且释放加速。将聚乙二醇（PEG）添加到纤维的壳层部分以进一步精细调节BSA的释放行为。结果表明，随着壳层部分PEG百分比的增加，BSA的释放速率提高。通过改变内层纺丝液的进料速率和PEG含量，大部分BSA可在1周至1个多月的时间内从核 - 壳结构纤维中释放出来。还通过扫描电子显微镜研究了内层纺丝液进料速率以及在壳层部分添加PEG对纤维形态的影响。（c）2006威利期刊公司
Biodegradable core-shell structured fibers with poly(E-caprolactone) as shell and bovine serum albumin (BSA)-containing dextran as core were prepared by coaxial electro-spinning for incorporation and controlled release of proteins. BSA loading percent in the fibers and its release rate could be conveniently varied by the feed rate of the inner dope during electrospinning. With the increase in the feed rate of the inner dope, there was an associated increase in the loading percent and accelerated release of BSA. Poly(ethylene glycol) (PEG) was added to the shell section of the fibers to further finely modulate the release behavior of BSA. It was revealed that the release rate of BSA increased with the PEG percent in the shell section. By varying the feed rate of the inner dope and PEG content, most of BSA could be released from the core-shell structured fibers within the period of time ranging from I week to more than 1 month. The effect of the feed rate of the inner dope and addition of PEG into the shell section on the fiber morphology was also examined by scanning electron microscope. (c) 2006 Wiley Periodicals, Inc.