Seroepidemiologic Effects of Influenza A(H1N1)pdm09 in Australia, New Zealand, and Singapore
Seroepidemiologic Effects of Influenza A(H1N1)pdm09 in Australia, New Zealand, and Singapore
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DOI：
10.3201/eid1901.111643
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发表时间：
2013-01-01
影响因子：
11.8
通讯作者：
Markey, Peter G.
中科院分区：
文献类型：
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作者：
Trauer, James M.;Bandaranayake, Don;Markey, Peter G.
为了估计 2009 年 6 月 8 月期间南半球 A(H1N1)pdm2009 流感的人群发病率，我们进行了多项血清学研究。我们汇集了在澳大利亚、新西兰和新加坡进行的使用血凝抑制测定的研究中的个体水平数据。我们按照辖区通知数据的定义，按年龄组和性别确定了每个研究区域在大流行前和后阶段的血清阳性比例（滴度> = 40）。排除后，汇总数据库由 4,414 项大流行前检测和 7,715 项大流行后检测组成。在大流行前阶段，年龄较大的群体表现出更高的血清阳性比例，年龄标准化、基于社区的比例范围从新加坡的 3.5% 到新西兰的 11.9%。在大流行后阶段，血清阳性比例从新加坡的17.5%到新西兰的30.8%不等，其中学龄儿童的比例最高。怀孕和住院护理与大流行后血清阳性率较低相关，而澳大利亚原住民和托雷斯海峡岛民以及新西兰太平洋居民的大流行后血清阳性率较高。
To estimate population attack rates of influenza A(H1N1)pdm2009 in the Southern Hemisphere during June August 2009, we conducted several serologic studies. We pooled individual-level data from studies using hemagglutination inhibition assays performed in Australia, New Zealand, and Singapore. We determined seropositive proportions (titer >= 40) for each study region by age-group and sex in pre- and postpandemic phases, as defined by jurisdictional notification data. After exclusions, the pooled database consisted of, 4,414 prepandemic assays and 7,715 postpandemic assays. In the prepandemic phase, older age groups showed greater seropositive proportions, with age-standardized, community-based proportions ranging from 3.5% in Singapore to 11.9% in New Zealand. In the postpandemic phase, seropositive proportions ranged from 17.5% in Singapore to 30.8% in New Zealand, with highest proportions seen in school-aged children. Pregnancy and residential care were associated with lower postpandemic seropositivity, whereas Aboriginal and Torres Strait Islander Australians and Pacific Peoples of New Zealand had greater postpandemic seropositivity.