Growth Restriction and Systemic Immune Development in Preterm Piglets
Growth Restriction and Systemic Immune Development in Preterm Piglets
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DOI：
10.3389/fimmu.2019.02402
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发表时间：
2019-10-10
影响因子：
7.3
通讯作者：
Duc Ninh Nguyen
中科院分区：
文献类型：
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作者：
Baek, Ole;Sangild, Per Torp;Duc Ninh Nguyen
背景：许多早产儿出生前因母体或胎儿并发症而患有生长受限（GR）。由于器官不成熟相关的疾病，无论出生体重（BW）如何，此类婴儿在出生后可能会继续缓慢生长。严重的GR会增加感染的易感性，但尚不清楚这是否是全身免疫力受损或其他因素（例如住院时间延长或粘膜屏障功能不良）的结果。使用早产猪作为早产儿的模型，我们假设适度的GR，发挥有限的临床效果，不会影响全身免疫发育。方法：早产猪通过剖腹产分娩，并饲喂牛乳饲料直至19天。胎儿生长受限仔猪（F-GR，BW 最低 25%，n = 27，不包括 BW 的仔猪）
Background: Many preterm infants are born with growth restriction (GR) following maternal or fetal complications before birth. Such infants may continue to grow slowly after birth, regardless of birth weight (BW), due to morbidities related to their immature organs. Severe GR increases the susceptibility to infections, but it is not clear if this is a consequence of impaired systemic immunity or other factors, such as prolonged hospital stay or poor mucosal barrier function. Using preterm pigs as models for preterm infants, we hypothesized that moderate GR, exerting limited clinical effects, does not influence systemic immune development.Methods: Preterm pigs were delivered by cesarean section and fed bovine milk diets until 19 d. Piglets with fetal growth restriction (F-GR, the lowest 25% of BW, n = 27, excluding those with BW