AJG series: molecular biology for clinicians.
AJG series: molecular biology for clinicians.
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AJG 系列：临床医生的分子生物学。
DOI：
10.1038/ajg.2009.319
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Talley,NicholasJ
中科院分区：
文献类型：
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作者：
Saito,YuriA;Talley,NicholasJ
药物遗传学是一个不断发展的领域，它提供了个体遗传密码与药物代谢和药物反应之间的联系。该领域提供了个性化药物选择和优化剂量的巨大希望，以最大限度地提高治疗反应并最大限度地减少不良副作用。随着我们对遗传变异对药物代谢和身体药物加工的作用的理解的增长，我们教育和告知患者对处方药物的预期治疗反应的能力也在增长。这篇简短的综述将概述遗传学、药物遗传学以及当前和未来预测胃肠道疾病药物反应的遗传变异的例子，以及这一令人兴奋和发展中领域的局限性和前景。
Pharmacogenetics is an evolving field that provides the link between an individual's genetic code and drug metabolism and drug response. This field offers the great promise of individualized medication selection and optimized dosage to maximize treatment response and to minimize adverse side effects. As our understanding of the role of the effects of genetic variants on drug metabolism and body drug processing grows, so does our ability to educate and inform our patients about expected treatment response to the medications being prescribed to them. This brief review will provide an overview of genetics, pharmacogenetics, and current and future examples of genetic variants predicting drug response in gastrointestinal disease, and the limitations and the promise of this exciting and developing field.