Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives:: Effect of alkyl chain length
Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives:: Effect of alkyl chain length
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DOI：
10.1016/j.bmcl.2008.02.020
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发表时间：
2008-07-15
影响因子：
2.7
通讯作者：
Kaihatsu, Kunihiro
中科院分区：
文献类型：
--
作者：
Mori, Shuichi;Miyake, Shinya;Kaihatsu, Kunihiro
一系列的脂肪酸单酯衍生物（ - ） - epigallocatechin-3-o-gallate（EGCG）通过一盘脂肪酶催化的式酯固定剂制备。长烷基链的引入增强了相对于天然EGCG的24倍的抗炎性A/PR8/34（H1N1）病毒活性。 （c）2008 Elsevier Ltd.保留所有权利。
A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG. (C) 2008 Elsevier Ltd. All rights reserved.