Age at Menarche and Risk of Type 2 Diabetes: Results From 2 Large Prospective Cohort Studies
Age at Menarche and Risk of Type 2 Diabetes: Results From 2 Large Prospective Cohort Studies
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DOI：
10.1093/aje/kwp372
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发表时间：
2010-02-01
影响因子：
5
通讯作者：
Hu, Frank B.
中科院分区：
文献类型：
--
作者：
He, Chunyan;Zhang, Cuilin;Hu, Frank B.
作者调查了来自护士健康研究 (NHS) 的 101,415 名 34-59 岁 (1980-2006) 女性和来自护士健康研究 II (NHS II) 的 100,547 名 26-46 岁 (1991-2005) 女性，初潮年龄与 2 型糖尿病 (T2DM) 风险之间的关联。在 2,430,274 人年和 1,373,875 人年的随访期间，分别记录了 7,963 例和 2,739 例 T2DM 病例。调整潜在混杂因素（包括 10 岁时的体形和 18 岁时的体重指数（BMI；体重 (kg)/身高 (m)(2)））后，初潮年龄较小与 T2DM 风险增加相关。不同初潮年龄类别（< 11、12、13、14 和 >= 15 岁）的 T2DM 相对风险分别为 1.18（95% 置信区间 (CI)：1.10、1.27）、1.09（95% CI：1.02、1.17）、1.00（参考）、0.92（95% CI： 0.83、1.01）和 0.95（95% CI：0.84， 在 NHS 中分别为 1.06）（趋势 P < 0.0001）和 1.40（95% CI：1.24、1.57）、1.13（95% CI：1.00、1.27）、1.00（参考）、0.98（95% CI：0.82、1.18）和 0.96 (95% CI: 0.78, 1.19)，分别在 NHS II 中（P 为趋势 < 0.0001)。在对更新的时变 BMI 进行额外控制后，相关性显着减弱。这些数据表明，初潮过早与成年期 T2DM 风险增加相关。这种关联可能很大程度上是通过成人过度肥胖介导的。这种关联在年轻女性中更为明显，除了 BMI 之外，性激素在 T2DM 年轻发病中也发挥着重要作用。
The authors investigated the association between age at menarche and risk of type 2 diabetes mellitus (T2DM) among 101,415 women from the Nurses' Health Study (NHS) aged 34-59 years (1980-2006) and 100,547 women from Nurses' Health Study II (NHS II) aged 26-46 years (1991-2005). During 2,430,274 and 1,373,875 person-years of follow-up, respectively, 7,963 and 2,739 incident cases of T2DM were documented. Young age at menarche was associated with increased risk of T2DM after adjustment for potential confounders, including body figure at age 10 years and body mass index (BMI; weight (kg)/height (m)(2)) at age 18 years. Relative risks of T2DM across age-at-menarche categories (< 11, 12, 13, 14, and >= 15 years) were 1.18 (95% confidence interval (CI): 1.10, 1.27), 1.09 (95% CI: 1.02, 1.17), 1.00 (referent), 0.92 (95% CI: 0.83, 1.01), and 0.95 (95% CI: 0.84, 1.06), respectively, in the NHS (P for trend < 0.0001) and 1.40 (95% CI: 1.24, 1.57), 1.13 (95% CI: 1.00, 1.27), 1.00 (referent), 0.98 (95% CI: 0.82, 1.18), and 0.96 (95% CI: 0.78, 1.19), respectively, in NHS II (P for trend < 0.0001). Associations were substantially attenuated after additional control for updated time-varying BMI. These data suggest that early menarche is associated with increased risk of T2DM in adulthood. The association may be largely mediated through excessive adult adiposity. The association was stronger among younger women, supporting a role for sex hormones in younger onset of T2DM, in addition to BMI.