Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.
Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.
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DOI：
10.1523/jneurosci.0460-12.2012
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发表时间：
2012-08-08
期刊：
影响因子：
--
通讯作者：
Häusser M
中科院分区：
文献类型：
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作者：
Duguid I;Branco T;London M;Chadderton P;Häusser M
滋补抑制是神经元令人兴奋和网络功能的关键调节剂，但其在感官信息处理中的作用仍然很少了解。小脑皮层，在体内允许高分辨率贴片夹记录，并且是小脑皮层中唯一表达含α6Δ的GABAA受体的神经元抑制作用。如何调节大鼠小脑中的感觉信息的传播，我们使用了来自单个颗粒细胞的细胞内记录和分子层中的体内，选择性药理学和体外动态夹具。或增强补品抑制作用会降低颗粒细胞区分持续的背景活动的能力。在颗粒细胞中的感觉传播和平行纤维突触输入与下游分子层中间神经元的信噪比。体内通过小脑皮层促进了感觉信息的流动。
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a highly favorable model system for addressing this problem as granule cells, which form the input layer of the cerebellar cortex, permit high-resolution patch clamp recordings in vivo, and are the only neurons in the cerebellar cortex that express the α6δ-containing GABAA receptors that mediate tonic inhibition. To investigate how tonic inhibition regulates the transmission of sensory information in the rat cerebellum we used a combination of intracellular recordings from single granule cells and molecular layer interneurons in vivo, selective pharmacology and in vitro dynamic clamp experiments. We show that surprisingly, blocking or enhancing tonic inhibition reduces the ability of granule cells to discriminate sensory signals from ongoing background activity. This is reflected in a reduction in the signal-to-noise ratio of sensory transmission in granule cells and of parallel fiber synaptic input to downstream molecular layer interneurons. Our results suggest that tonic inhibition can dynamically modulate sensory transmission in the cerebellum, and that under basal conditions the level of tonic inhibition in vivo facilitates the flow of sensory information through the cerebellar cortex.