T helper type 2 like cytokine responses to peptides from P0 and P2 myelin proteins during the recovery phase of Guillain-Barre syndrome
T helper type 2 like cytokine responses to peptides from P0 and P2 myelin proteins during the recovery phase of Guillain-Barre syndrome
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DOI：
10.1016/s0022-510x(97)00178-0
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发表时间：
1997-12-09
影响因子：
4.4
通讯作者：
Ernerudh, J
中科院分区：
文献类型：
--
作者：
Dahle, C;Ekerfelt, C;Ernerudh, J
T淋巴细胞可能参与了格林-巴利综合征（GBS）的发病机制。辅助性T细胞-1（Th 1）细胞因子激活巨噬细胞并诱导迟发型超敏反应（DTH）炎症反应，与CBS中脱髓鞘的形态学一致。Th 2细胞因子促进抗体产生并下调Th 1应答。为了研究Th 1/Th 2细胞因子与GBS临床过程的关系，使用ELISPOT方法测定分泌干扰素-γ、IFN-γ（Th 1）或白细胞介素-4、IL-4（Th 2）的单细胞。我们连续研究了抗原诱导的细胞因子分泌的循环T细胞刺激的人肽从P0和P2蛋白在7例患者和比较的结果从7个连续研究的健康对照。与对照组相比，大多数患者（7例中的5例）在平台期或恢复期显示出IL-4应答。另一方面，一名病程延长的患者具有IFN-γ主导的反应性。我们认为，IL-4的反应是有益的GBS，并可能有一个作用，在终止疾病的过程中，这种自限性炎症性疾病。(C)1997年Elsevier Science B.V.
T-lymphocytes are probably involved in the pathogenesis of Guillain-Barre syndrome (GBS). T-helper-1 (Th1) cytokines activate macrophages and induce a delayed type hypersensitivity (DTH) inflammatory response, consistent with the morphology of the demyelination in CBS. Th2 cytokines encourage antibody production and downregulate Th1 responses. To study the Th1/Th2 cytokines in relation to the clinical course of GBS an ELISPOT method for determination of single cells secreting interferon-gamma, IFN-gamma (Th1) or interleukin-4, IL-4 (Th2) was used. We serially investigated antigen-induced cytokine secretion from circulating T-cells stimulated with human peptides from the P0 and P2 proteins in seven patients and compared to results from seven serially investigated healthy controls. Most patients (five of seven) showed IL-4 responses during the plateau- or recovery-phase as compared to controls. One patient with a prolonged disease course, on the other hand, had an IFN-gamma dominated reactivity. We suggest that the IL-4 responses are beneficial in GBS, and may have a role in terminating the disease process in this self-limiting inflammatory disease. (C) 1997 Elsevier Science B.V.