Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs.
Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs.
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DOI：
10.1155/2010/424161
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发表时间：
2010
影响因子：
--
通讯作者：
Davidson BJ
中科院分区：
文献类型：
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作者：
Ahmadi N;Goldman R;Seillier-Moiseiwitsch F;Noone AM;Kosti O;Davidson BJ
我们通过对71例头颈部鳞状细胞癌（HNSCC）病例和相同数量的健康对照者进行标准化问卷调查，评估非甾体抗炎药（NSAID）在头颈部鳞状细胞癌（HNSCC）中使用的化学预防作用。使用非甾体抗炎药可使HNSCC发生风险降低75%。使用非甾体抗炎药的频率显著降低了风险。限制阿司匹林使用者的分析显示，发生HNSCC的风险显著降低90%。这项研究为非甾体抗炎药使用者，特别是阿司匹林使用者，发生HNSCC的风险显著降低提供了证据。
We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.