Affiliation and disease risk: social networks mediate gut microbial transmission among rhesus macaques
Affiliation and disease risk: social networks mediate gut microbial transmission among rhesus macaques
复制标题
DOI：
10.1016/j.anbehav.2019.03.009
复制
发表时间：
2019-05-01
期刊：
影响因子：
2.5
通讯作者：
McCowan, Brenda
中科院分区：
文献类型：
--
作者：
Balasubramaniam, Krishna N.;Beisner, Brianne A.;McCowan, Brenda
在社会动物中，亲和行为带来了许多好处，但也带来了疾病风险等成本。隶属关系如何影响传染性病原体传播的风险仍不清楚。此外，将亲和相互作用的变化与传染性病原体发病率/多样性联系起来的研究推测可能发生了疾病传播，而不是揭示确实发生了传播。我们解决这些差距，利用大肠埃希氏菌，以确定是否亲和梳理和蜷缩社交网络介导的微生物在恒河猴之间的传播的遗传学。我们收集了成年猕猴在12周内的行为和微生物数据，分为两个6周的阶段，以更好地检测二元传播。我们从亲和相互作用中重建了无向社交网络，并从E.大肠杆菌pulsotypes从猕猴内和跨相邻的采样事件。猕猴E与环境分离株相比，大肠杆菌脉冲型之间的遗传相似性更高，这为社会介导的传播奠定了前提。二元梳理和蜷缩频率强烈影响E。大肠杆菌的传播在第二个数据收集阶段，但不是第一个。在梳理和聚集网络中更中心/连接良好的猕猴在E.大肠杆菌传播网络。我们的研究结果证实，亲和梳理和蜷缩行为介导肠道微生物在恒河猴之间的传播，特别是在雌性和高级个体之间。社会介导的E.大肠杆菌的传播可能部分地被雄性的环境获得或被圈养中的高频率相互作用所掩盖。预测胃肠道寄生虫和病原体的潜在传播途径，我们的研究结果增加了目前的知识亲和行为和健康之间的共同进化关系，并可用于确定“超级传播者”个人作为疾病控制策略的潜在目标。(C)2019动物行为研究协会。由爱思唯尔有限公司出版。保留所有权利。
In social animals, affiliative behaviours bring many benefits, but also costs such as disease risk. The ways in which affiliation may affect the risk of infectious agent transmission remain unclear. Moreover, studies linking variation in affiliative interactions to infectious agent incidence/diversity have speculated that disease transmission may have occurred, rather than revealing that transmission did occur. We address these gaps using the phylogenetics of commensal gut Escherichia coli to determine whether affiliative grooming and huddling social networks mediated microbial transmission among rhesus macaques. We collected behavioural and microbial data from adult macaques across a 12-week period that was split into two 6-week phases to better detect dyadic transmission. We reconstructed undirected social networks from affiliative interactions and reconstructed microbial transmission networks from the pairwise phylogenetic similarity of E. coli pulsotypes from macaques within and across adjacent sampling events. Macaque E. coli pulsotypes were more phylogenetically similar to each other than to environmental isolates, which established a premise for socially mediated transmission. Dyadic grooming and huddling frequencies strongly influenced the likelihood of E. coli transmission during the second data collection phase, but not the first. Macaques that were more central/well connected in both their grooming and huddling networks were also more central in the E. coli transmission networks. Our results confirmed that affiliative grooming and huddling behaviours mediate the transmission of gut microbes among rhesus macaques, particularly among females and high-ranking individuals. The detectability of socially mediated E. coli transmission maybe partially masked by environmental acquisition in males, or by high frequencies of interactions in captivity. Predicting the potential transmission pathways of gastrointestinal parasites and pathogens, our findings add to current knowledge of the coevolutionary relationships between affiliative behaviour and health and may be used to identify 'superspreader' individuals as potential targets for disease control strategies. (C) 2019 The Association for the Study of Animal Behaviour. Published by Elsevier Ltd. All rights reserved.