Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy
Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy
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DOI：
10.1002/ana.10171
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发表时间：
2002-05-01
影响因子：
11.2
通讯作者：
Jackson, GD
中科院分区：
文献类型：
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作者：
Briellmann, RS;Berkovic, SF;Jackson, GD
这项对24例轻度颞叶癫痫患者的纵向定量磁共振成像研究显示，在3.5 +/- 0.7年的时间内，同侧海马体积减少9%（范围，-30至+0.5%; p = 0.002，配对t检验）。海马体积丢失与扫描之间的全身性癫痫发作次数相关（P = 0.0007，r = 0.6），提示癫痫相关的海马损伤。
This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, -30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 +/- 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (P = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.