Synaptic strengthening through activation of Ca2+-permeable AMPA receptors
Synaptic strengthening through activation of Ca2+-permeable AMPA receptors
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DOI：
10.1038/381793a0
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发表时间：
1996-06-27
期刊：
影响因子：
64.8
通讯作者：
MacDermott, AB
中科院分区：
文献类型：
--
作者：
Gu, JG;Albuquerque, C;MacDermott, AB
突触传递过程中突触后钙的升高是脊椎动物中枢神经系统突触强度短期和长期变化的重要触发因素(1)。AMPA(alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate)受体是谷氨酸受体的一个亚家族，在大脑和脊髓中介导了大部分兴奋性突触传递(2)。已经证明，AMPA受体的一个亚型是钙离子通透性的(3-6)，存在于神经元的亚群中(7-12)。当突触定位时，这些受体应该介导突触后钙离子的内流，为突触强度的变化提供触发。在这里，我们发现钙离子通透性的AMPA受体位于背角神经元的突触亚群上，它们提供了一条突触门控的钙进入途径，这些受体的激活加强了AMPA受体介导的突触传递。这种突触后钙离子内流的途径可能为突触强度的活性依赖性调节提供了一种新的形式。
POSTSYNAPTIC Ca2+ elevation during synaptic transmission is an important trigger for short- and long-term changes in synaptic strength in the vertebrate central nervous system(1). The AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate) receptors, a subfamily of glutamate receptors, mediate much of the excitatory synaptic transmission in the brain and spinal cord(2). It has been shown that a subtype of the AMPA receptor is Ca2+ -permeable(3-6) and is present in subpopulations of neurons(7-12). When synaptically localized(13), these receptors should mediate postsynaptic Ca2+ influx, providing a trigger for changes in synaptic strength. Here we show that Ca2+-permeable AMPA receptors are synaptically localized on a subpopulation of dorsal horn neurons, that they provide a synaptically gated route of Ca2+ entry, and that activation of these receptors strengthens synaptic transmission mediated by AMPA receptors. This pathway for postsynaptic Ca2+ influx may provide a new form of activity-dependent modulation of synaptic strength.