Amyloid beta and postoperative delirium: partners in crime or strangers in the dark?
Amyloid beta and postoperative delirium: partners in crime or strangers in the dark?
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β 淀粉样蛋白和术后谵妄：犯罪同伙还是黑暗中的陌生人？
DOI：
10.1016/j.bja.2023.05.009
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发表时间：
2023
影响因子：
9.8
通讯作者：
Berger,Miles
中科院分区：
文献类型：
--
作者：
Reekes,TylerH;Devinney,MichaelJ;Berger,Miles
术后谵妄是手术和围手术期护理的一种特别使人衰弱的并发症。虽然术后谵妄的病因还不完全清楚，最近的证据表明，阿尔茨海默病和相关的痴呆病理学在术后谵妄的发展中起着重要的作用。最近一项评价术后血浆β淀粉样蛋白（Aβ）水平变化的研究发现，术后期间Aβ升高，但与术后谵妄发生率和严重程度的相关性不同。这些发现支持了这样的观点：阿尔茨海默病和相关痴呆病理学与血脑屏障功能障碍和神经炎症相结合可能会带来术后谵妄的风险。
Postoperative delirium is a particularly debilitating complication of surgery and perioperative care. Although the aetiology of postoperative delirium is not entirely understood, recent evidence suggests that Alzheimer's disease and related dementias pathology plays an important role in the development of postoperative delirium. A recent study evaluating postoperative changes in plasma beta amyloid (Aβ) levels found increased Aβ across the postoperative period, but the association with postoperative delirium incidence and severity was variable. These findings support the idea that Alzheimer's disease and related dementias pathology in combination with blood–brain barrier dysfunction and neuroinflammation may impart risk for postoperative delirium.