Antifungal activity of gold nanoparticles prepared by solvothermal method
Antifungal activity of gold nanoparticles prepared by solvothermal method
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DOI：
10.1016/j.materresbull.2012.09.069
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发表时间：
2013-01-01
影响因子：
5.4
通讯作者：
Al-Shihri, Ayed S.
中科院分区：
文献类型：
--
作者：
Ahmad, Tokeer;Wani, Irshad A.;Al-Shihri, Ayed S.
以SnCl2和NaBH4为还原剂，采用溶剂热法成功地合成了金纳米粒子。X射线衍射研究表明，具有面心立方结构的金纳米粒子具有高度的结晶性和单相性质。透射电子显微镜研究表明，使用SnCl2可以得到平均尺寸为15 nm的近球形金纳米颗粒，而使用NaBH4可以得到平均粒径为7 nm的高度均匀、单分散的球形金纳米颗粒。7 nm金纳米粒子的比表面积为329m(2)/g，15 nm金纳米粒子的比表面积为269m(2)/g。UV-Vis研究证实了横向和纵向表面等离子体激元在可见光区的激发。金纳米粒子表现出良好的尺寸依赖性抗真菌活性和对念珠菌的更强的杀菌作用，因为7 nm的金纳米粒子比15 nm的金纳米粒子限制了念珠菌的跨膜H+外流。(C)2012爱思唯尔有限公司。保留所有权利。
Gold nanoparticles have been successfully synthesized by solvothermal method using SnCl2 and NaBH4 as reducing agents. X-ray diffraction studies show highly crystalline and monophasic nature of the gold nanoparticles with face centred cubic structure. The transmission electron microscopic studies show the formation of nearly spherical gold nanoparticles of average size of 15 nm using SnCl2, however, NaBH4 produced highly uniform, monodispersed and spherical gold nanoparticles of average grain size of 7 nm. A high surface area of 329 m(2)/g for 7 nm and 269 m(2)/g for 15 nm gold nanoparticles was observed. UV-vis studies assert the excitations over the visible region due to transverse and longitudinal surface plasmon modes. The gold nanoparticles exhibit excellent size dependant antifungal activity and greater biocidal action against Candida isolates for 7 nm sized gold nanoparticles restricting the transmembrane H+ efflux of the Candida species than 15 nm sized gold nanoparticles. (C) 2012 Elsevier Ltd. All rights reserved.