Intracranial mast cells contribute to the control of social behavior in male mice
Intracranial mast cells contribute to the control of social behavior in male mice
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DOI：
10.1016/j.bbr.2021.113143
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发表时间：
2021-01
影响因子：
2.7
通讯作者：
D. Tanioka;S. Chikahisa;Noriyuki Shimizu;T. Shiuchi;N. Sakai;S. Nishino;H. Sei
中科院分区：
文献类型：
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作者：
D. Tanioka;S. Chikahisa;Noriyuki Shimizu;T. Shiuchi;N. Sakai;S. Nishino;H. Sei
肥大细胞（MCs）存在于啮齿类动物的颅内，据报道，肥大细胞影响大脑的高级功能。然而，MCs在调节情绪和社会行为中的作用尚不清楚。本研究以雄性小鼠为研究对象，探讨了MCs与社会行为之间的关系，并探讨了其潜在机制。野生型雄性小鼠在室内注射MCs脱粒剂后，在三室社交测试中表现出明显的增加。此外，在肥大细胞特异性毒素受体介导的条件细胞敲除（mass - treck）雄性小鼠中，去除MCs在三室社交测试中显示出社会偏好水平降低，而没有其他行为改变，如焦虑样和抑郁样行为。Mas-TRECK雄性小鼠大脑中血清素含量和血清素受体表达减少，催产素受体表达增加。这些结果提示MCs可能参与雄性小鼠社会行为的调节。这种作用可能部分由大脑中MCs产生的血清素介导。
Mast cells (MCs) exist intracranially and have been reported to affect higher brain functions in rodents. However, the role of MCs in the regulation of emotionality and social behavior is unclear. In the present study, using male mice, we examined the relationship between MCs and social behavior and investigated the underlying mechanisms. Wild-type male mice intraventricularly injected with a degranulator of MCs exhibited a marked increase in a three-chamber sociability test. In addition, removal of MCs in Mast cell-specific Toxin Receptor-mediated Conditional cell Knock out (Mas-TRECK) male mice showed reduced social preference levels in a three-chamber sociability test without other behavioral changes, such as anxiety-like and depression-like behavior. Mas-TRECK male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. These results suggested that MCs may contribute to the regulation of social behavior in male mice. This effect may be partially mediated by serotonin derived from MCs in the brain.