Epidermal-dermal interactions in adult skin.
Epidermal-dermal interactions in adult skin.
复制标题
成人皮肤的表皮-真皮相互作用。
DOI：
10.1111/1523-1747.ep12544628
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Briggaman,RA
中科院分区：
文献类型：
--
作者：
Briggaman,RA
表皮-真皮相互作用是皮肤中胚胎发育的重要决定因素。本文综述了这种表皮-真皮相互作用在成人皮肤上皮特异性保护中的作用。基本的表皮角化程序被定义为增殖的基底细胞群、细胞的有序分层细胞分化和角质层的产生，可以由成人表皮表达，而不持续存在特定的真皮。表皮与非真皮结缔组织充分分化的能力证明了这一点。包括角膜和食管在内的其他几种上皮细胞表达其特异性分化特征，而不持续存在特异性结缔组织。另一方面，成人皮肤中的某些区域上皮特异性可由真皮决定。这些区域性表皮特异性涉及表皮厚度、包括角质层在内的表皮隔室的大小以及表皮-真皮界面处的折叠模式的改变。真皮可以控制这些区域特征的可能机制进行了讨论。表皮-真皮重组技术已被用来确定在动物的各种遗传性皮肤异常的基因作用的网站。类似的研究报告，利用成年人皮肤在裸鼠长期培养。板层状鱼鳞病的异常基因直接作用于表皮。泛发性剥脱性银屑病也进行了研究重组技术。表皮和真皮都需要维持银屑病的形态，这表明一个复杂的多基因机制或涉及遗传和环境因素。
Epidermal-dermal interactions are important determinants of embryonic development in skin. This review examines the role of such epidermal-dermal interactions in the conservation of epithelial specificity in adult skin. The basic epidermal keratinization program as defined as a proliferative basal cell population, orderly stratified cytodifferentiation of the cells and production of stratum corneum can be expressed by adult epidermis without the continued presence of a specific dermis. This is evidenced by the ability of epidermis to differentiate fully in association with nondermal connective tissues. Several other epithelia including cornea and esophagus express their specific differentiative characteristics without the continued presence of specific connective tissue. On the other hand, certain regional epithelial specificities in adult skin may be determined by the dermis. These regional epidermal specificities involve alterations in epidermal thickness, size of epidermal compartments including the stratum corneum, and the folding pattern at the epidermal-dermal interface. Possible mechanisms by which dermis could control these regional characteristics are discussed.Epidermal-dermal recombination techniques have been used to define the site of gene action in a variety of inherited skin abnormalities in animals. Similar studies are reported utilizing adult human skin in long-term cultivation on nude athymic mice. The abnormal gene in lamellar ichthyosis exerts its effect directly on the epidermis. Generalized exfoliative psoriasis was also studied by recombination techniques. Both epidermis and dermis were required for the maintenance of psoriatic morphology, suggesting a complex polygenic mechanism or one involving both genetic and environmental factors.