Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis
Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis
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DOI：
10.1007/s11033-011-0863-6
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发表时间：
2012-02-01
影响因子：
2.8
通讯作者：
Wu, Xiao-Ting
中科院分区：
文献类型：
--
作者：
Chen, Bo;Zhou, Yong;Wu, Xiao-Ting
调查 X 射线修复交叉互补基因 1 (XRCC1) 多态性与胃癌 (GC) 风险之间关系的研究报告了相互矛盾的结果。我们对已发表的病例对照和队列研究进行了荟萃分析，以更好地比较研究之间的结果。检索了 PubMed、EMBASE 和中国国家知识基础设施中发表的文献。选择了 18 项研究，涉及 3,915 例 GC 病例和 6,759 例对照。对于XRCC1 Arg194Trp多态性，我们仅发现Trp/Trp基因型携带者可能具有GC高风险（TT vs. CC+CT：OR = 1.31，95% CI = 1.04-1.65）。在按种族分层时，结果显示亚洲人（尤其是华人）的胃癌病例和对照之间的基因型分布存在显着差异，但白种人中则没有显着差异。对对照来源进行分层时，仅在医院对照亚组中观察到 Arg194Trp 多态性与 GC 风险之间的显着关联（TT 与 CC+CT：OR = 1.45，95% CI = 1.13-1.87）。此外，在贲门癌亚组中未检测到显着关联。总体荟萃分析的结果并未表明 Arg280His/Arg399Gln 多态性与所有遗传模型的 GC 易感性之间存在任何关联。在基于研究设计、种族、国家、肿瘤位置、幽门螺杆菌感染和 GC 劳伦分类的亚组分析中，没有证据表明这两种基因多态性与 GC 风险之间存在关联。总之，XRCC1 Arg194Trp 纯合突变基因型 (Trp/Trp) 被发现与 GC 风险增加相关。
Studies investigating the association between X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and gastric cancer (GC) risk have reported conflicting results. We performed a meta-analysis of published case-control and cohort studies to better compare results between studies. Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure were retrieved. 18 studies with 3,915 GC cases and 6,759 controls were selected. For XRCC1 Arg194Trp polymorphism, we only found the Trp/Trp genotype carriers might be at high risk of GC (TT vs. CC+CT: OR = 1.31, 95% CI = 1.04-1.65). When stratifying for ethnicity, the results showed there was a significant difference in genotype distribution between GC cases and controls among Asians (especially, in Chinese population), but not among Caucasians. When stratifying for control sources, significant association between Arg194Trp polymorphism and GC risk was only observed in the hospital-based controls' subgroup (TT vs. CC+CT: OR = 1.45, 95% CI = 1.13-1.87). Additionally, no significant association was detected in the gastric cardia cancer's subgroup. The results of the overall meta-analysis did not suggest any association between Arg280His/Arg399Gln polymorphisms and GC susceptibility for all genetic models. There was no evidence for the association between these two gene polymorphisms and GC risk in subgroup analyses based on study design, ethnicity, country, tumor location, Helicobacter pylori infection and the Lauren's classification of GC. In conclusion, XRCC1 Arg194Trp homozygous mutant genotype (Trp/Trp) was found to be associated with increased risk of GC.