Postsynaptic supersensitivity in schizophrenia.
Postsynaptic supersensitivity in schizophrenia.
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精神分裂症的突触后超敏反应。
DOI：
10.1176/ajp.134.5.518
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
John M. Davis
中科院分区：
文献类型：
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作者：
G. Pandey;D. Garver;Carol A. Tamminga;Stephen Ericksen;S. Ali;John M. Davis
在精神分裂症多巴胺假说的背景下，作者通过神经内分泌策略检测了精神分裂症患者突触后多巴胺（DA）受体的敏感性，使用DA受体激动剂阿波啡和生长激素（GH）释放作为可测量的突触后事件。血小板腺苷酸环化酶（一种与儿茶酚胺受体活性密切相关的酶）的活性也在前列腺素E1 （PGE1）刺激后进行了研究。诊断为急性精神分裂症的患者的生长激素反应和腺苷酸环化酶活性明显高于正常对照和诊断为慢性精神分裂症的患者。慢性精神分裂症伴和不伴迟发性运动障碍患者的生长激素反应略低于对照组，但与对照组无显著差异。
In the context of the dopamine hypothesis of schizophrenia, the authors examined postsynaptic dopamine (DA) receptor sensitivity in schizophrenic patients by means of a neuroendocrine strategy using the DA receptor agonist apomorphine and growth hormone (GH) release as the measurable postsynaptic event. The activity of platelet adenylate cyclase, an enzyme intimately associated with catecholamine receptor activity, was also studied following stimulation by prostaglandin E1 (PGE1). Patients diagnosed as having acute schizophrenia had significantly higher GH responses and adenylate cyclase activity than normal control subjects and patients diagnosed as having chronic schizophrenia. Chronic schizophrenic patients with and without tardive dyskinesia showed GH responses slightly lower than but not significantly different from those of control groups.