Ferrate(VI) oxidation of propranolol: Kinetics and products
Ferrate(VI) oxidation of propranolol: Kinetics and products
复制标题
DOI：
10.1016/j.chemosphere.2012.12.001
复制
发表时间：
2013-03-01
期刊：
影响因子：
8.8
通讯作者：
Oturan, Mehmet A.
中科院分区：
文献类型：
--
作者：
Anquandah, George A. K.;Sharma, Virender K.;Oturan, Mehmet A.
通过动力学、化学计量和反应产物分析，研究了高铁酸盐 (VI) (Fe(VI)) 对 β 阻滞剂普萘洛尔 (PPL) 的氧化作用。 Fe(VI) 氧化 PPL 的速率定律对于每种反应物都是一阶的。利用 Fe(VI) 和 PPL 的酸碱平衡解释了 Fe(VI) 和 PPL 反应的二阶速率常数对 pH 的依赖性。完全去除 PPL 所需的摩尔化学计量确定为 6:1 ([Fe(VI):[PPL])。使用液相色谱-串联质谱法鉴定的产物是氧化产物(OP)-292、OP-308和OP-282。形成的OPs可能会与母体分子竞争与Fe(VI)反应，从而导致PPL的降解与Fe(VI)添加量之间的非线性关系。速率和去除研究表明，Fe(VI) 能够氧化 PPL，因此也可以氧化其他 β 受体阻滞剂，例如阿替洛尔和美托洛尔。 (c) 2012 Elsevier Ltd. 保留所有权利。
The oxidation of propranolol (PPL), a beta-blocker by ferrate(VI) (Fe(VI)) was studied by performing kinetics, stoichiometry, and analysis of the reaction products. The rate law for the oxidation of PPL by Fe(VI) was first-order with respect to each reactant. The dependence of second-order rate constants of the reaction of Fe(VI) and PPL on pH was explained using acid-base equilibrium of Fe(VI) and PPL. The required molar stoichiometry for the complete removal of PPL was determined to be 6:1 ([Fe(VI):[PPL]). The identified products using liquid chromatography-tandem mass spectrometry were oxidized product (OP)-292, OP-308, and OP-282. The formed OPs could possibly compete with the parent molecule to react with Fe(VI) and thus resulted in a non-linear relationship between degradation of PPL and the added amount of Fe(VI). Rate and removal studies indicate the Fe(VI) is able to oxidize PPL and hence can also oxidize other beta-blockers, e.g., atenolol and metoprolol. (c) 2012 Elsevier Ltd. All rights reserved.