Taurine Deficiency in Tissues Aggravates Radiation-Induced Gastrointestinal Syndrome
Taurine Deficiency in Tissues Aggravates Radiation-Induced Gastrointestinal Syndrome
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组织中牛磺酸缺乏会加剧辐射诱发的胃肠道综合症
DOI：
10.1007/978-3-030-93337-1_10
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ma Ning
中科院分区：
文献类型：
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作者：
Yamashita Takenori;Kato Toshihiro;Isogai Tamami;Gu Yeunhwa;Ito Takashi;Ma Ning
用于癌症治疗或核电站事故的电离辐射是辐射暴露的两个常见原因。电离辐射暴露会产生活性氧和自由基，从而导致氧化应激。我们以前曾报道牛磺酸有助于辐射损伤的恢复，这表明它作为辐射防护剂和辐射缓释剂的潜力。然而，牛磺酸对放射诱导的胃肠道综合征的影响仍然知之甚少。本研究的目的是观察牛磺酸对放射性胃肠道综合征的影响。采用全身X射线照射的方法，建立Taut+/+和Taut−/−小鼠放射性胃肠综合征模型。观察小鼠30天存活率、小肠隐窝绒毛结构及增殖细胞核抗原(PCNA)阳性细胞的增殖情况。Taut−/−小鼠的存活率显著低于Taut+/+小鼠。紧张型−/−小鼠小肠绒毛明显短于紧张型+/+小鼠。此外，Taut−/−组小鼠的增殖细胞核抗原+细胞数明显少于Taut+/+组。这些数据表明，牛磺酸是隐窝干细胞的关键调节因子，在肠道细胞的生存、增殖和命运中起着重要的调节作用。因此，牛磺酸可能会减少放射性胃肠综合征。
Ionizing radiation administered for cancer treatment or from nuclear plant accidents are two common causes of radiation exposure. Ionizing radiation exposure generates reactive oxygen species and free radicals, which cause oxidative stress. We previously reported that taurine contributes to the recovery from radiation-induced injuries, suggesting its potential as a radioprotector and radiation mitigator. However, the effect of taurine on radiation-induced gastrointestinal syndrome remains poorly understood. The aim of this study was to examine the effect of taurine tissue depletion on radiation-induced gastrointestinal syndrome. Mouse models of radiation-induced gastrointestinal syndrome were established in TauT+/+ and TauT−/− mice by whole-body X-irradiation. We examined the 30-day survival rate, as well as the crypt-villus structure and proliferation of proliferating cell nuclear antigen (PCNA) + cells in the small intestine. The survival rate of TauT−/− mice was significantly lower than that of TauT+/+ mice. The villi in the small intestine of TauT−/− mice were significantly shorter than those in TauT+/+ mice. Additionally, there were significantly fewer PCNA+ cells in TauT−/− mice than in TauT+/+ mice. These data demonstrate that taurine is a key regulator of crypt stem cells and plays an important regulatory role in intestinal cell survival, proliferation, and fate. Therefore, taurine may reduce radiation-induced gastrointestinal syndrome.