Tumor versus vascular photodamage in a rat tumor model.
Tumor versus vascular photodamage in a rat tumor model.
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大鼠肿瘤模型中的肿瘤与血管光损伤。
DOI：
10.1016/s1011-1344(98)00155-9
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Morgan,A
中科院分区：
文献类型：
--
作者：
Kessel,D;Hampton,J;Fingar,V;Morgan,A
发现[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺(FANFT)诱导的大鼠尿路上皮肿瘤表达mdr基因。由此产生的多药耐药性（MDR）表型导致向外转运系统的表达，该系统可防止某些弱阳离子药物在细胞内积聚。后者是一种已知对 FANFT 肿瘤有效的光敏剂，即铜苯并氯亚胺盐。 FANFT 细胞受到保护，免受该药物介导的直接细胞杀伤，表明这种肿瘤/敏化剂组合导致的肿瘤再生的显着延迟可归因于血管效应。
The [4-(5-nitro-2-furyl)-2-thiazoyl] formamide (FANFT)-induced urothelial tumor in the rat is found to express the mdr gene. The resulting multidrug resistance (MDR) phenotype results in the expression of an outward transport system that prevents cellular accumulation of certain weakly cationic agents. Among the latter is a photosensitizer with known efficacy for the FANFT tumor, the copper benzochlorin iminium salt. FANFT cells are protected from direct cell kill mediated by this drug, suggesting that the substantial delay in tumor regrowth from this tumor/sensitizer combination can be attributed to vascular effects.