Facile preparation of mussel-inspired polyurethane hydrogel and its rapid curing behavior.
Facile preparation of mussel-inspired polyurethane hydrogel and its rapid curing behavior.
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DOI：
10.1021/am502106e
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发表时间：
2014-07
影响因子：
9.5
通讯作者：
Peiyu Sun;Jing Wang;Xiong Yao;Ying Peng;Xiaoxiong Tu;P. Du;Zhen Zheng;Xinling Wang
中科院分区：
文献类型：
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作者：
Peiyu Sun;Jing Wang;Xiong Yao;Ying Peng;Xiaoxiong Tu;P. Du;Zhen Zheng;Xinling Wang
一种简便的方法被发现可将一种受贻贝启发的黏附部分引入合成聚合物中，并且受贻贝启发的聚氨酯被开发为黏附性水凝胶。在这些聚合物中，聚氨酯主链取代了贻贝黏附蛋白的聚酰胺链，并且添加了多巴胺以模拟黏附蛋白的黏附部分。通过基于六亚甲基二异氰酸酯作为硬段、具有不同分子量的聚乙二醇作为软段以及赖氨酸 - 多巴胺作为扩链剂的逐步增长聚合反应，制备了一系列受贻贝启发的聚氨酯。在用Fe(3+)处理后，受贻贝启发的聚氨酯水溶液可通过调节pH值触发，瞬间形成黏附性水凝胶；这些材料可用作可注射的黏附性水凝胶。在用高碘酸钠处理后，受贻贝启发的聚氨酯溶液可在可控的时间段内固化。独特的受贻贝启发的黏附部分与可调节的聚氨酯结构的成功结合可产生一种新型的受贻贝启发的黏附聚合物。
A facile method was found to incorporate a mussel-inspired adhesive moiety into synthetic polymers, and mussel mimetic polyurethanes were developed as adhesive hydrogels. In these polymers, a urethane backbone was substituted for the polyamide chain of mussel adhesive proteins, and dopamine was appended to mimic the adhesive moiety of adhesive proteins. A series of mussel mimetic polyurethanes were created through a step-growth polymerization based on hexamethylene diisocyanate as a hard segment, PEG having different molecular weights as a soft segment, and lysine-dopamine as a chain extender. Upon a treatment with Fe(3+), the aqueous mussel mimetic polyurethane solutions can be triggered by pH adjustment to form adhesive hydrogels instantaneously; these materials can be used as injectable adhesive hydrogels. Upon a treatment with NaIO4, the mussel mimetic polyurethane solutions can be cured in a controllable period of time. The successful combination of the unique mussel-inspired adhesive moiety with a tunable polyurethane structure can result in a new kind of mussel-inspired adhesive polymers.