Antibody persistence in five-year-old children who received a pentavalent combination vaccine in infancy
Antibody persistence in five-year-old children who received a pentavalent combination vaccine in infancy
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DOI：
10.1097/00006454-200206000-00011
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发表时间：
2002-06-01
影响因子：
3.6
通讯作者：
Lundin, C
中科院分区：
文献类型：
--
作者：
Carlsson, RM;Claesson, BA;Lundin, C
背景在婴儿期完成白喉类毒素、破伤风类毒素、无细胞百日咳、灭活脊髓灰质炎和流感嗜血杆菌B型结合疫苗联合疫苗试验的5.5岁瑞典儿童中研究了抗体持久性。在2 - 4 - 6个月龄时的三次引发剂量诱导的所有抗原抗体的几何平均浓度高于3 - 5个月龄时的两次剂量，但保护性抗体浓度的比例没有差异。分别在13或12月龄时给予加强剂量后，两组之间的浓度或比例没有差异。在目前的随访中，228名接种者中有180名（88名来自4剂组，92名来自3剂组）的血清样本在4.5年后再次进行抗体检测。除脊髓灰质炎病毒3型外，两组的抗体浓度或比例没有显着差异，抗体高于保护水平或其他规定水平（P小于或等于0.01）。通过酶联免疫吸附试验，89%的患者白喉抗体≥ 0.01 IU/ml，通过Vero细胞中和试验，76%的患者破伤风抗体≥ 0.01 IU/ml，96 - 99%的患者脊髓灰质炎病毒抗体可检测，97%的患者H.流感病毒B型抗体。对于百日咳，酶联免疫吸附试验检测百日咳类毒素抗体的阳性率为44%，而中国仓鼠卵巢细胞中和试验检测百日咳类毒素抗体的阳性率为99%，丝状血凝素抗体的阳性率为94%。我们发现抗体的持久性是令人满意的，根据婴儿期三剂或四剂计划接种的儿童之间的抗体浓度没有临床相关差异。
Background. Antibody persistence was studied in 5.5-year-old Swedish children who in infancy completed a vaccine trial of a combined diphtheria toxoid, tetanus toxoid, acellular pertussis, inactivated polio and Haemophilus influenzae type b conjugate vaccine. Three priming doses at ages 2-4-6 months induced higher geometric mean concentrations of antibodies for all antigens than did two doses at 3-5 months, but there were no differences in proportions with protective antibody concentrations. After the booster dose administered at 13 or 12 months of age, respectively, there were no differences in concentrations or proportions between the groups.Methods. In the present follow-up serum samples from 180 of the 228 vaccinees, 88 from the 4-dose and 92 from the 3-dose group, were 4.5 years later again tested for antibodies.Results. The two groups did not differ significantly in antibody concentrations or proportions with antibodies above protective or other defined levels, with the exception of poliovirus type 3 (P less than or equal to 0.01). In all 89% had greater than or equal to0.01 IU/ml antibodies against diphtheria by enzyme-linked immunosorbent assay and 76% by the Vero cell neutralization test, 93% had greater than or equal to0.01 IU/ml antibodies against tetanus, 96 to 99% had detectable antibodies against the polioviruses and 97% had greater than or equal to0.15 mug/ml H. influenzae type b antibodies. As for pertussis only 44% had detectable antibodies against pertussis toxoid by enzyme-linked immunosorbent assay but 99% by Chinese hamster ovary cell neutralization test, and 94% had detectable antibodies against filamentous hemagglutinin.Conclusion. We found the persistence of antibodies satisfactory, with no clinically relevant differences in antibody concentrations demonstrated between children vaccinated according to a three dose or a four dose schedule in infancy.