Rapid increase in PKA activity during long-term potentiation in the hippocampal afferent fibre system to the prefrontal cortex in vivo
Rapid increase in PKA activity during long-term potentiation in the hippocampal afferent fibre system to the prefrontal cortex in vivo
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DOI：
10.1046/j.1460-9568.1998.00389.x
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发表时间：
1998-10-01
影响因子：
3.4
通讯作者：
Yamaguchi, T
中科院分区：
文献类型：
--
作者：
Jay, TM;Gurden, H;Yamaguchi, T
本研究旨在探讨cAMP依赖性蛋白激酶（PKA）是否参与在体海马前额叶皮层传入纤维系统的长时程增强（LTP）过程。利用生物化学方法，我们测量PKA活性在不同的时间诱导后的LTP。我们发现，有一个NMDA受体依赖性增加PKA活性在前额叶皮层，只有在5分钟后LTP诱导，这些数据表明PKA的诱导作用，而不是皮质LTP的表达，并建议，如果PKA参与了LTP的晚期阶段，它似乎不是一个持久的激活。
The purpose of the present study was to examine whether cAMP-dependent protein kinase (PKA) was implicated in the process of long-term potentiation (LTP) in the hippocampal afferent fibre system to the prefrontal cortex in vivo. Using a biochemical approach, we measured PKA activity at different limes after induction of LTP. We show that there is an NMDA receptor-dependent increase in PKA activity in the prefrontal cortex, only at five minutes after LTP induction, These data demonstrate a role of PKA in the induction and not the expression of cortical LTP and suggest that if PKA is involved in the late phase of LTP, it does not appear to be a persistent activation.