Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122
Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122
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DOI：
10.1021/acs.orglett.2c00781
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发表时间：
2022-04-15
期刊：
影响因子：
5.2
通讯作者：
Li, Xin
中科院分区：
文献类型：
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作者：
Yan, Li-Hong;Li, Pei-Hai;Li, Xin
从深海冷渗型真菌AspergilluschvalieriCS-122中分离得到两种吲哚二酮基哌嗪生物碱Chvalinulins A(1)和B(2)，它们都含有一个前所未有的螺环[二环[2.2.2]辛烷-二酮哌嗪]骨架，以及一个已知的类似物新棘球菌素B(3)。通过光谱分析、单晶X射线衍射、比旋光度(SR)和核磁共振计算确定了化合物1和2的结构。化合物1和2在转基因斑马鱼体内具有显著的促血管生成活性。
Chevalinulins A (1)andB(2), two indolediketopiperazine alkaloids containing an unprecedented spiro-[bicyclo[2.2.2]octane-diketopiperazine] skeleton, together with aknown analogue neoechinulin B (3), were isolated from the deep-sea cold-seep-derived fungusAspergillus chevalieriCS-122. Theirstructures were determined by spectroscopic analysis, single-crystalX-ray diffraction, specific rotation (SR), and NMR calculations.Compounds1and2exhibited significantin vivoproangiogenicactivity in transgenic zebrafish.