ENHANCED DETECTION OF FOCAL BRAIN RESPONSES USING INTERSUBJECT AVERAGING AND CHANGE-DISTRIBUTION ANALYSIS OF SUBTRACTED PET IMAGES
ENHANCED DETECTION OF FOCAL BRAIN RESPONSES USING INTERSUBJECT AVERAGING AND CHANGE-DISTRIBUTION ANALYSIS OF SUBTRACTED PET IMAGES
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DOI：
10.1038/jcbfm.1988.111
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发表时间：
1988-10-01
影响因子：
6.3
通讯作者：
RAICHLE, ME
中科院分区：
文献类型：
--
作者：
FOX, PT;MINTUN, MA;RAICHLE, ME
开发并测试了减影正电子发射断层扫描（PET）图像的受试者间平均值和变化分布分析。这些技术的目的是提高灵敏度和客观性的功能映射的人脑PET。为了允许图像平均化，使用立体定向解剖定位和层间插值将所有原始断层扫描图像转换为解剖学标准化三维图像。图像噪声，控制减去控制减法测量，强烈抑制平均。信噪比，测量刺激减去控制减法（手振动减去闭眼休息），稳步上升平均，证实了我们的解剖标准化方法的准确性。CBF变化图像的分布分析（通过gamma-2统计的离群值检测）被评估为区域神经元活动的状态依赖性变化的综合检验。检测体感反应的灵敏度随着平均值的增加而稳步上升，从单个图像的50%增加到三个或更多图像的平均值时的100%。在所有平均水平下的特异性均为100%。虽然这里描述为利用H215 O CBF图像进行功能性脑映射的技术，但是图像平均和变化分布分析是更普遍适用的技术，而不限于单一目的或示踪剂。
Intersubject averaging and change-distribution analysis of subtracted positron emission tomographic (PET) images were developed and tested. The purpose of these techniques is to increase the sensitivity and objectivity of functional mapping of the human brain with PET. To permit image averaging, all primary tomographic images were converted to anatomically standardized three-dimensional images using stereotactic anatomical localization and interslice interpolation. Image noise, measured in control-minus-control subtractions, was strongly suppressed by averaging. Signal-to-noise ratio, measured in stimulus-minus-control subtractions (hand vibration minus eyes-closed rest), rose steadily with averaging, confirming the accuracy of our method of anatomical standardization. Distribution analysis of CBF change images (outlier detection by gamma-2 statistic) was assessed as an omnibus test for state-dependent changes in regional neuronal activity. Sensitivity in detecting the somatosensory response rose steadily with averaging, increasing from 50% in individual images to 100% when three or more images were averaged. Specificity was 100% at all averaging levels. Although described here as a technique for functional brain mapping with H215O CBF images, image averaging, and change-distribution analysis are more generally applicable techniques, not limited to a single purpose or tracer.