On the scale-up of micro-reactors for liquid–liquid reactions
On the scale-up of micro-reactors for liquid–liquid reactions
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DOI：
10.1016/j.ces.2015.12.009
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发表时间：
2016-04
影响因子：
4.7
通讯作者：
P. Plouffe;Michael Bittel;Jonas Sieber;D. Roberge;A. Macchi
中科院分区：
文献类型：
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作者：
P. Plouffe;Michael Bittel;Jonas Sieber;D. Roberge;A. Macchi
使用 3/7 方法研究了带有专为液-液反应设计的混合器的微反应器的放大，该方法在增加的流速下缩放水力直径并保持平均能量耗散率恒定。使用单相压降测量和液-液反应萃取来比较小型 (dh283 µm) 和大型 (dh714 µm) 混合器。单相测试表明，在流量大约 8.5 倍的情况下，较大规模混合器的能量耗散率与较小规模混合器相当。两种规模混合器的反应萃取的总体积传质系数 Kca 在液滴流状态中能量耗散率相等时也相似。最后，讨论了分级方法的上限，并与市售静态混合器进行了比较。
The scale-up of a micro-reactor with a mixer designed for liquid–liquid reactions is investigated using a 3/7th approach that scales the hydraulic diameter at increased flow rates and keeps constant the average rate of energy dissipation. Smaller (dh283 µm) and larger-scale (dh714 µm) mixers are compared using single phase pressure drop measurements and a liquid–liquid reactive extraction. The single phase tests demonstrate that the energy dissipation rate of the larger scale mixer is comparable to the smaller scale mixer at flow rates ~8.5 times greater. The overall volumetric mass transfer coefficients of the reactive extraction, Kca, of both scale mixers were also similar at equal energy dissipation rate in the drop flow regime. Finally, the upper limit of the sizing approach is discussed and compared with commercially available static mixers.