Refining Dynamics of Gene Regulatory Networks in a Stochastic p-Calculus Framework
Refining Dynamics of Gene Regulatory Networks in a Stochastic p-Calculus Framework
复制标题
随机 p 微积分框架中基因调控网络的精细化动力学
DOI：
10.1007/978-3-642-19748-2_8
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
O. Roux
中科院分区：
文献类型：
--
作者：
Loïc Paulevé;Morgan Magnin;O. Roux
In this paper, we introduce a framework allowing to model and analyse efficiently Gene Regulatory Networks (GRNs) in their temporal and stochastic aspects. The analysis of stable states and inference of Rene Thomas' discrete parameters derives from this logical formalism. We offer a compositional approach which comes with a natural translation to the Stochastic π-Calculus. The method we propose consists in successive refinements of generalised dynamics of GRNs. We illustrate the merits and scalability of our framework on the control of the differentiation in a GRN generalising metazoan segmentation processes, and on the analysis of stable states within a large GRN studied in the scope of breast cancer researches.
影响因子：
1.1
作者：
Ciocchetta, Federica;Hillston, Jane
通讯作者：
Hillston, Jane