Reproducibility of peripapillary retinal nerve fiber thickness measurements with stratus OCT in glaucomatous eyes
Reproducibility of peripapillary retinal nerve fiber thickness measurements with stratus OCT in glaucomatous eyes
复制标题
DOI：
10.1016/j.ophtha.2007.05.035
复制
发表时间：
2008-04-01
期刊：
影响因子：
13.7
通讯作者：
Anderson, Douglas R.
中科院分区：
文献类型：
--
作者：
Budenz, Donald L.;Fredette, Marie-Josee;Anderson, Douglas R.
用途：确定Stratus OCT视盘周围视网膜神经纤维层（RNFL）测量在青光眼眼中的可重复性。设计：实验研究。参与者：51例严重程度不同的稳定型青光眼患者。方法：使用Stratus光学相干断层扫描（OCT）的标准和快速扫描方案测量瞳孔周围RNFL厚度在同一天进行3次，以确定期内变异性，在2个月内的5个不同日期进行3次，以确定期间变异性。相同的仪器由相同的操作员使用的所有scans.Main结果测量：组内相关系数（ICC），变异系数（COV），和重测variability.Results：平均RNFL厚度，intrasession和intersession ICC为标准和快速扫描分别为0.98和0.96。COV范围为3.8%至5.2%。测试之间的重测变异性约为7 gm，其中大部分可归因于每次测试中约5 μ m的变异性。对于象限，ICC为0.9或更高，COV低于10%，鼻除外。象限测量的重测变异性范围为6至16 μ m。对于时钟小时，重测变异接近20亩在某些部门的会议之间。一般而言，鼻区的ICC低于其他部位。RNFL厚度测定区域越小，变异性越大。在个体受试者中，会话内变异性不是会话间变异性的预测因子（P标准= 0.72，P快速=0.28）。变异性和平均RNFL厚度之间没有关系（P标准= 0.28，P快速= 0.93）。结论：RNFL厚度的Stratus OCT的再现性足够好，可用于临床作为青光眼进展的测量。当比较同一只眼睛在不同日期的2个平均RNFL值时，厚度减少8 μ m可能被接受为在95%公差的重测变异性的正常范围内。对于象限和时钟小时扇区，可变性更高，需要更详细的计算。
Purpose: To determine the reproducibility of Stratus OCT peripapillary retinal nerve fiber layer (RNFL) measurements in glaucomatous eyes.Design: Experimental study.Participants: Fifty-one stable glaucoma patients with a range of severity.Methods: Peripapillary RNFL thickness was measured using the Standard and Fast scan protocols of Stratus optical coherence tomography (OCT) 3 times on the same day to determine intrasession variability and on 5 different days within a 2-month period to determine intersession variability. The same instrument was used by the same operator for all scans.Main Outcome Measures: Intraclass correlation coefficient (ICC), coefficient of variation (COV), and test-retest variability.Results: For mean RNFL thickness, the intrasession and intersession ICCs for the Standard and Fast scans were 0.98 and 0.96, respectively. The COV ranged from 3.8% to 5.2%. Test-retest variability was approximately 7 gm between sessions, most of which can be attributed to the approximate 5-mu m variability within each session. For quadrants, the ICC was 0.9 or higher and the COV was under 10% except nasally. Test-retest variability for quadrant measurements ranged from 6 to 16 mu m. For clock hours, test-retest variability approached 20 mu m between sessions in some sectors. In general, the ICC was lower in the nasal region than elsewhere. Variability was greater the smaller the area over which RNFL thickness was determined. Intrasession variability was not a predictor of intersession variability in individual subjects (P Standard = 0.72, P Fast =0.28). There was no relationship between variability and mean RNFL thickness (P Standard = 0.28, P Fast = 0.93).Conclusions: The reproducibility of Stratus OCT for RNFL thickness is sufficiently good to be useful clinically as a measure of glaucoma progression. When comparing 2 mean RNFL values on different days in the same eye, an 8-mu m decrease in thickness might be accepted as within normal limits of test-retest variability with 95% tolerance. For quadrants and clock-hour sectors, variability is higher, and more detailed calculations are necessary.