Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics

Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics
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DOI：
10.1085/jgp.201812235
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发表时间：
2019-12
期刊：
The Journal of General Physiology
影响因子：
--
通讯作者：
T. Yamazawa;H. Ogawa;T. Murayama;M. Yamaguchi;H. Oyamada;Junji Suzuki;N. Kurebayashi;Kazunori Kanemaru;K. Oguchi;Takashi Sakurai;M. Iino
T. Yamazawa;H. Ogawa;T. Murayama;M. Yamaguchi;H. Oyamada;Junji Suzuki;N. Kurebayashi;Kazunori Kanemaru;K. Oguchi;Takashi Sakurai;M. Iino
中科院分区：
其他
文献类型：
--
作者：
T. Yamazawa;H. Ogawa;T. Murayama;M. Yamaguchi;H. Oyamada;Junji Suzuki;N. Kurebayashi;Kazunori Kanemaru;K. Oguchi;Takashi Sakurai;M. Iino

文献摘要

相似文献

研究了携带疾病相关突变的RYR1 N端区域中Ca2+释放通道活性致病性增强的分子基础。功能研究和分子动力学模拟表明，结构域之间的相互作用与通道活性有很强的相关性。
Molecular bases of pathogenic enhancement of Ca2+ release channel activities in RYR1 carrying disease-associated mutations at the N-terminal region were studied. Functional studies and MD simulation revealed that the interactions between domains have a strong correlation with channel activity.