The role of HMGB1 in inflammation-mediated organ injury.
The role of HMGB1 in inflammation-mediated organ injury.
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DOI：
10.1016/j.aat.2013.03.007
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发表时间：
2013-03-01
期刊：
影响因子：
--
通讯作者：
Ma, Daqing
中科院分区：
文献类型：
--
作者：
Asavarut, Paladd;Zhao, Hailin;Ma, Daqing
HMGB1是一种染色体结合蛋白，也是一种损伤相关的分子模式分子。它具有强有力的促炎作用，是器官损伤的关键介质之一。来自研究的证据已经揭示其参与Toll样受体和器官损伤中晚期糖基化终产物受体的信号传导机制。HMGB 1介导的器官损伤是急性损伤，包括缺血性、机械性、同种异体移植排斥和毒性，以及心脏、肾脏、肺和大脑的慢性疾病。针对HMGB1及其相关细胞信号通路的策略需要开发，并可能在器官损伤中具有预防和治疗潜力。
HMGB1 is a chromosome-binding protein that also acts as a damage-associated molecular pattern molecule. It has potent proinflammatory effects and is one of key mediators of organ injury. Evidence from research has revealed its involvement in the signaling mechanisms of Toll-like receptors and the receptor for advanced glycation end-products in organ injury. HMGB1-mediated organ injuries are acute damage including ischemic, mechanical, allograft rejection and toxicity, and chronic diseases of the heart, kidneys, lungs, and brain. Strategies against HMGB1 and its associated cellular signal pathways need to be developed and may have preventive and therapeutic potentials in organ injury.