Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2
Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2
复制标题
MicroRNA-137 的缺失会通过 KCC2 损害神经元中钾的稳态
DOI：
10.5607/en19072
复制
发表时间：
2020-04-01
影响因子：
2.4
通讯作者：
Teng, Zhao-Qian
中科院分区：
文献类型：
--
作者：
Mi, Ting-Wei;Sun, Xiao-Wen;Teng, Zhao-Qian
Neuropsychiatric disorders are the leading cause of mental and intellectual disabilities worldwide. Current therapies against neuropsychiatric disorders are very limited, and very little is known about the onset and development of these diseases, and their most effective treatments. MIR137 has been previously identified as a risk gene for the etiology of schizophrenia, bipolar disorder, and autism spectrum disorder. Here we generated a forebrain-specific MIR137 knockout mouse model, and provided evidence that loss of miR-137 resulted in impaired homeostasis of potassium in mouse hippocampal neurons. KCC2, a potassium-chloride co-transporter, was a direct downstream target of miR-137. The KCC2 specific antagonist VU0240551 could balance the current of potassium in miR-137 knockout neurons, and knockdown of KCC2 could ameliorate anxiety-like behavior in MIR137 cKO mice. These data suggest that KCC2 antagonists or knockdown might be beneficial to neuropsychiatric disorders due to the deficiency of miR-137.
