Human bocavirus: A novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand
Human bocavirus: A novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand
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DOI：
10.1086/512163
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发表时间：
2007-04-01
影响因子：
6.4
通讯作者：
Olsen, Sonja J.
中科院分区：
文献类型：
--
作者：
Fry, Alicia M.;Lu, Xiaoyan;Olsen, Sonja J.
背景。我们在泰国农村地区住院的肺炎患者中检测到 4.5% 的人博卡病毒 (HBoV) 感染。然而，HBoV 作为病原体的作用尚不清楚。方法。我们对2004年9月1日至2005年8月31日期间在泰国同一家医院入组的肺炎患者和无症状对照患者的HBoV感染情况进行了比较。我们对患有流感样疾病的门诊患者进行了 HBoV 感染检查，并检测了另外 13 种呼吸道病毒。描述了 HBoV 感染的流行病学和临床特征。结果。 512 名门诊患者中有 20 名 (3.9%) 检测出 HBoV 感染，280 名对照患者中有 3 名 (1%) 检测出 HBoV 感染。 83%的肺炎患者和90%的门诊患者检测到与其他病毒的混合感染。与对照患者相比，HBoV 感染与需要住院治疗的肺炎显着相关（调整后优势比，3.56 [95% 置信区间，1.06-11.91]；P = .04）。 83% 的 HBoV 感染是在 5 岁以下的肺炎患者中检测到的。与仅感染 RSV 和 HPIV 的患者相比，与 HBoV-呼吸道合胞病毒 (RSV) 或人副流感病毒 (HPIV) 合并感染相关的肺炎患者出现喘息的人数较多（17 人中的 9 人 [53%] vs. 138 人中的 32 人 [23%]；P =.01）。结论。流行病学上，HBoV 感染与泰国农村幼儿中的肺炎相关，但感染和疾病可能取决于与其他病毒的合并感染。
Background. We detected human bocavirus (HBoV) infection in 4.5% of hospitalized patients with pneumonia in rural Thailand. However, the role of HBoV as a pathogen is unclear.Methods. We compared HBoV infection in patients with pneumonia with that in asymptomatic control patients enrolled between 1 September 2004 and 31 August 2005 in the same hospitals in Thailand. We examined outpatients with influenza-like illness for HBoV infection and tested for 13 additional respiratory viruses. Epidemiologic and clinical characteristics of HBoV infection are described.Results. HBoV infection was detected in 20 (3.9%) of 512 outpatients and 3 (1%) of 280 control patients. Coinfection with other viruses was detected in 83% of patients with pneumonia and in 90% of outpatients. Compared with control patients, HBoV infection was significantly associated with pneumonia requiring hospitalization (adjusted odds ratio, 3.56 [95% confidence interval, 1.06-11.91]; P = .04). Eighty-three percent of HBoV infections were detected in patients with pneumonia who were < 5 years old. More patients with pneumonia associated with HBoV-respiratory syncytial virus (RSV) or human parainfluenza virus (HPIV) coinfections had wheezing than patients with RSV and HPIV infections alone (9 [53%] of 17 vs. 32 [23%] of 138]; P =.01).Conclusions. HBoV infection was epidemiologically associated with pneumonia among young children in rural Thailand, but infection and illness may be dependent on coinfection with other viruses.