Dissociation of autonomic and behavioral components of conditioned fear during development in the rat.
Dissociation of autonomic and behavioral components of conditioned fear during development in the rat.
复制标题
大鼠发育过程中条件性恐惧的自主神经和行为成分的分离。
DOI：
10.1037//0735-7044.99.6.1089
复制
发表时间：
1985
影响因子：
1.9
通讯作者：
Ampuero,MX
中科院分区：
文献类型：
--
作者：
Campbell,BA;Ampuero,MX
在不受限制的断奶前和断奶（16-，19-，21-，25-，和28日龄）大鼠的心率（HR）的经典条件反射检查，与音调和光作为条件刺激（CS）和电击作为非条件刺激。条件性心脏反应是HR持续减速，对于张力CS，直到第21天才出现，对于轻度CS，直到第28天才出现。相比之下，当抑制行为反应（在直巷中跑步以获得干乳作为奖励）用作条件反射的指标时，CS的抑制作用在第16天左右对色调和第19天左右对光线明显。这些发现表明，在个体发育过程中，（a）对相同条件刺激的行为和自主反应并不以相同的速度发展，（B）对音调和光刺激的条件反应的出现与相关感觉模态达到成熟的顺序平行（第一次试镜，下一个愿景），及（c）没有清楚的─切断HR定向反应的发展与HR的条件性之间的相互依赖性，因为听觉和视觉的无条件心脏减速刺激第一次出现在发育中的大鼠中约第16天，远在对任一刺激建立条件性HR反应之前。
Classical conditioning of heart rate (HR) was examined in unrestrained preweanling and weanling (16-, 19-, 21-, 25-, and 28-day-old) rats, with tone and light as the conditioned stimuli (CS) and electric shock as the unconditioned stimulus. The conditioned cardiac response was a sustained deceleration in HR which did not emerge until Day 21 for the tone CS and until Day 28 for the light CS. In contrast, when suppression of a behavioral response (running in a straight alley for dry suckling as reward) was used as the index of conditioning, the suppressive effects of the CS were evident around Day 16 for the tone and around Day 19 for the light. These findings indicate that during ontogenesis (a) the behavioral and autonomic responses to the same conditioned stimulus do not develop at the same pace,(b) the emergence of conditioned responses to tone and light stimuli parallel the sequential order in which the relevant sensory modalities achieve maturity (first audition, next vision), and (c) there is no clear-cut interdependence between development of the HR orienting response and conditionability of HR because unconditioned cardiac deceleration to both auditory and visual stimuli first appears about Day 16 in the developing rat, well before conditioned HR responses can be established to either stimulus.