Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer's Disease: Using Morris Water Maze and Micro-PET.
Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer's Disease: Using Morris Water Maze and Micro-PET.
复制标题
DOI：
10.1155/2015/142129
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Jiang J;Gao K;Zhou Y;Xu A;Shi S;Liu G;Li Z
导论.阿尔茨海默病（Alzheimer's disease，AD）是一种进行性海马功能障碍，导致学习记忆能力下降和海马葡萄糖摄取率降低的疾病。更重要的是，AD没有有效的治疗方法。在这项研究中，我们评估了电针在加速衰老的小鼠8（SAMP 8）的有益和保护作用。法在电针范式中，对7.5月龄SAMP 8雄性小鼠每天进行一次电针治疗，持续15天。在正常对照范式和AD对照组中，7.5月龄SAMR 1雄性小鼠和SAMP 8雄性小鼠在电针组治疗的同时，采用抓包包扎法，以保证治疗条件相同，每日1次，共15天。结果Morris水迷宫实验发现电针治疗能提高SAMP 8小鼠的空间学习记忆能力，micro-PET实验证明电针治疗后海马葡萄糖摄取率水平高于正常对照组。结论这些结果表明，电针治疗可能为AD提供一种可行的治疗选择。
Introduction. Alzheimer's disease (AD) causes progressive hippocampus dysfunctions leading to the impairment of learning and memory ability and low level of uptake rate of glucose in hippocampus. What is more, there is no effective treatment for AD. In this study, we evaluated the beneficial and protective effects of electroacupuncture in senescence-accelerated mouse prone 8 (SAMP8). Method. In the electroacupuncture paradigm, electroacupuncture treatment was performed once a day for 15 days on 7.5-month-old SAMP8 male mice. In the normal control paradigm and AD control group, 7.5-month-old SAMR1 male mice and SAMP8 male mice were grabbed and bandaged while electroacupuncture group therapy, in order to ensure the same treatment conditions, once a day, 15 days. Results. From the Morris water maze (MWM) test, we found that the treatment of electroacupuncture can improve the spatial learning and memory ability of SAMP8 mouse, and from the micro-PET test, we proved that after the electroacupuncture treatment the level of uptake rate of glucose in hippocampus was higher than normal control group. Conclusion. These results suggest that the treatment of electroacupuncture may provide a viable treatment option for AD.
登录
查看更多内容
DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
9.8
作者：
Chen, X. -M.;Xu, J.;Wang, X. -R.
通讯作者：
Wang, X. -R.
影响因子：
2.9
作者：
Guo, Fan;Song, Wenying;Xiong, Lize
通讯作者：
Xiong, Lize
影响因子：
6.6
作者：
Chung, Ka-Fai;Yeung, Wing-Fai;Wong, Vivian Taam
通讯作者：
Wong, Vivian Taam