Structural correlates of motor adaptation deficits in patients with acute focal lesions of the cerebellum
Structural correlates of motor adaptation deficits in patients with acute focal lesions of the cerebellum
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DOI：
10.1007/s00221-014-3956-3
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发表时间：
2014-09-01
影响因子：
2
通讯作者：
Timmann, Dagmar
中科院分区：
文献类型：
--
作者：
Burciu, Roxana Gabriela;Reinold, Johanna;Timmann, Dagmar
采用现代病变-症状映射技术对小脑患者进行的研究为小脑对运动适应的贡献提供了宝贵的见解。在小脑慢性局灶性病变的患者中，使伸手运动适应力场（FF）和视旋转（VM）扰动的过程依赖于主要位于上级手部区域内的不同解剖结构。相比之下，在手下区的区域内的结果不太一致。补偿机制可能掩盖了手下部区域的作用。为了验证这一假设，在24例急性和亚急性小脑病变患者中研究了对FF和VM扰动的适应。采集高分辨率磁共振图像进行基于体素的病变-症状映射（VLSM）。VLSM证实，不同的，只有部分重叠的地区主要位于境内的上级手区是至关重要的适应FF和VM。更具体地说，目前的结果增加了以前的研究结果，小叶V是特别重要的FF适应，而小叶VI起着更重要的作用VM适应。没有明确的证据表明，在这两个任务的贡献的手的下部区域被发现。达到适应似乎主要取决于小脑内的上级手区。
Studies of cerebellar patients employing modern lesion-symptom mapping techniques have provided valuable insights into the contribution of the cerebellum to motor adaptation. In patients with chronic focal lesions of the cerebellum, the process of adapting reaching movements to force field (FF) and visuomotor rotation (VM) perturbations relies on different anatomical structures located primarily within the territory of the superior hand area. By contrast, results within the territory of the inferior hand area are less consistent. Compensatory mechanisms may have masked the contribution of the inferior hand area. To test this hypothesis, reaching adaptation to FF and VM perturbations was investigated in 24 patients with acute and subacute lesions of the cerebellum. High-resolution magnetic resonance images were acquired to perform voxel-based lesion-symptom mapping (VLSM). VLSM confirmed that distinct and only partially overlapping areas located primarily within the territory of the superior hand area were crucial for adaptation to FF and VM. More specifically, current results add to previous findings that lobule V is of particular importance in FF adaptation, whereas lobule VI plays a more important role in VM adaptation. No clear evidence for a contribution of the inferior hand area to either task was found. Reach adaptation appears to depend primarily on the superior hand area within the cerebellum.