NEUROLOGICAL SIGNS IN ALZHEIMERS-DISEASE
NEUROLOGICAL SIGNS IN ALZHEIMERS-DISEASE
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DOI：
10.1093/ageing/20.1.45
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发表时间：
1991-01-01
期刊：
影响因子：
6.7
通讯作者：
LEVY, R
中科院分区：
文献类型：
--
作者：
BURNS, A;JACOBY, R;LEVY, R
对178名符合NINCDS/ADRDA阿尔茨海默病诊断标准的患者进行了神经体征评估。鼻部反射占41%，锥体外系体征占12%，药物引起的锥体外系体征占3%，肌阵挛占5%，癫痫发作史占3%。抓握反射、锥体外系体征和症状与严重的认知功能障碍相关。在CT扫描上，锥体外系体征与第三脑室增大和基底节钙化、抓握反射伴额叶萎缩和癫痫病史伴左颞叶萎缩相关。在12个月的随访中，出现抓握反射的患者侧脑室大小较大。锥体外系体征和原始反射与较高的死亡率相关。
Neurological signs were assessed in 178 patients satisfying NINCDS/ADRDA criteria for Alzheimer's disease. A snout reflex was present in 41%, extrapyramidal signs in 12%, drug-induced extrapyramidal signs in 3%, myoclonus in 5%, and a history of epileptic fits in 3%. A grasp reflex, extrapyramidal signs and symptoms were associated with severe cognitive impairment. On CT scanning, extrapyramidal signs were associated with increased 3rd ventricular size and basal ganglia calcification, a grasp reflex with frontal lobe atrophy and a history of epilepsy with left temporal lobe atrophy. Lateral ventricular size was greater in patients developing a grasp reflex during a 12 month follow-up. Extrapyramidal signs and primitive reflexes were associated with a higher mortality.