Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory.
Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory.
复制标题
血清素转运蛋白基因的遗传变异影响识别记忆过程中 ERP 的新/旧效应。
DOI：
10.1016/j.neuropsychologia.2015.09.028
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发表时间：
2015
期刊：
影响因子：
2.6
通讯作者：
Nyhus,Erika
中科院分区：
文献类型：
--
作者：
Ross,RobertS;Medrano,Paolo;Boyle,Kaitlin;Smolen,Andrew;Curran,Tim;Nyhus,Erika
再认记忆是指对先前刺激进行再认的能力，它与时间和空间上不同的事件相关电位（ERP）有关。5-羟色胺转运体基因（SLC6A4）的等位基因变异最近被证明会影响记忆力。SLC6A4基因的5-羟色胺转运蛋白连锁多态性区域（5HTTLPR）的常见变体导致长（1）和短（s）等位基因变体，其中s等位基因的携带者具有降低的转录效率。因此，本研究探讨了SLC6A4基因多态性对识别记忆的表现和ERP振幅的影响。当60名参与者执行项目和源记忆识别任务时，收集了他们的脑电图（EEG）、遗传和行为数据。在这两项任务中，参与者学习并编码了200个单词，然后在检索过程中将其与200个新词混合。参与者在每个记忆任务的检索部分进行EEG监测。EEG电极分为四个ROI，左前上级、右前上级、左后上级和右后上级。ERP平均振幅在项目和源记忆任务中的命中进行了比较，正确识别新项目（正确拒绝）。结果表明，s-载体在源记忆任务期间在刺激后1000 - 1500 ms的右前上级ROI和在项目记忆任务期间在刺激后300 - 500 ms的左前上级ROI中具有降低的平均撞击幅度。这些结果表明，由于5-羟色胺转运体基因的遗传变异的个体差异影响识别记忆。
Recognition memory is defined as the ability to recognize a previously encountered stimulus and has been associated with spatially and temporally distinct event-related potentials (ERPs). Allelic variations of the serotonin transporter gene (SLC6A4) have recently been shown to impact memory performance. Common variants of the serotonin transporter-linked polymorphic region (5HTTLPR) of the SLC6A4 gene result in long (l) and short (s) allelic variants with carriers of the s allele having lowered transcriptional efficiency. Thus, the current study examines the effects polymorphisms of the SLC6A4 gene have on performance and ERP amplitudes commonly associated with recognition memory. Electroencephalogram (EEG), genetic, and behavioral data were collected from sixty participants as they performed an item and source memory recognition task. In both tasks, participants studied and encoded 200 words, which were then mixed with 200 new words during retrieval. Participants were monitored with EEG during the retrieval portion of each memory task. EEG electrodes were grouped into four ROIs, left anterior superior, right anterior superior, left posterior superior, and right posterior superior. ERP mean amplitudes during hits in the item and source memory task were compared to correctly recognizing new items (correct rejections). Results show that s-carriers have decreased mean hit amplitudes in both the right anterior superior ROI 1000–1500 ms post stimulus during the source memory task and the left anterior superior ROI 300–500 ms post stimulus during the item memory task. These results suggest that individual differences due to genetic variation of the serotonin transporter gene influences recognition memory.