Reproductive Biology and Endocrinology Open Access the Krüppel-like Factor 9 (klf9) Network in Hec-1-a Endometrial Carcinoma Cells Suggests the Carcinogenic Potential of Dys-regulated Klf9 Expression
Reproductive Biology and Endocrinology Open Access the Krüppel-like Factor 9 (klf9) Network in Hec-1-a Endometrial Carcinoma Cells Suggests the Carcinogenic Potential of Dys-regulated Klf9 Expression
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通讯作者：
F. Simmen;Ying Su;R. Xiao;Z. Zeng;R. Simmen;Ying;Rijin;Zhaoyang Edu;Zeng
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作者：
F. Simmen;Ying Su;R. Xiao;Z. Zeng;R. Simmen;Ying;Rijin;Zhaoyang Edu;Zeng
背景资料：Krüppel样因子9（KLF 9）是子宫内膜细胞增殖、粘附和分化的转录调节因子;这些过程对于妊娠成功至关重要，并且在肿瘤发生期间被破坏。KLF 9控制的子宫内膜基因网络在很大程度上是未知的。与KLF 9低表达的HEC-1-A细胞相比，KLF 9在人子宫内膜癌细胞系HEC-1-A中的过表达改变了细胞形态、增殖指数和分化。该细胞系为鉴定KLF 9下游基因靶点和信号通路提供了独特的模型。
Background: Krüppel-like factor 9 (KLF9) is a transcriptional regulator of uterine endometrial cell proliferation, adhesion and differentiation; processes essential for pregnancy success and which are subverted during tumorigenesis. The network of endometrial genes controlled by KLF9 is largely unknown. Over-expression of KLF9 in the human endometrial cancer cell line HEC-1-A alters cell morphology, proliferative indices, and differentiation, when compared to KLF9 under-expressing HEC-1-A cells. This cell line provides a unique model for identifying KLF9 downstream gene targets and signaling pathways.