PROMINENT DIFFERENCES IN SHARP WAVES, RIPPLES AND COMPLEX SPIKE BURSTS BETWEEN THE DORSAL AND THE VENTRAL RAT HIPPOCAMPUS
PROMINENT DIFFERENCES IN SHARP WAVES, RIPPLES AND COMPLEX SPIKE BURSTS BETWEEN THE DORSAL AND THE VENTRAL RAT HIPPOCAMPUS
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DOI：
10.1016/j.neuroscience.2017.03.050
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发表时间：
2017-06-03
期刊：
影响因子：
3.3
通讯作者：
Papatheodoropoulos, Costas
中科院分区：
文献类型：
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作者：
Kouvaros, Stylianos;Papatheodoropoulos, Costas
海马体的功能沿着其长轴分离，新的证据表明局部电路相应地专门化。尖波（SPW）和波纹是与记忆处理有关的基本海马网络活动。使用大鼠海马背侧 (DH) 和腹侧 (VH) 切片 CA1 区的记录，我们发现 VH 中的 SPW 比 DH 中更大、更短且出现频率更高。 SPW 簇（即根据 NMDA 受体按序列分组的多个连续事件）在 VH 中发生的概率更高，并且连续簇内事件发生的频率在 VH（类似于 10 Hz）中比在 DH（类似于 5 Hz）中更高。纹波振荡在 VH 中显示出比在 DH 中更高的幅度和频率，并且与在 DH 中相比，在 VH 中纹波波的较晚相位处相关联的多单元发射峰值。与 DH 相比，VH 中的孤立单元复合体尖峰爆发显示出明显更少的尖峰数量和更长的尖峰间间隔，表明 VH 中突触驱动的神经元兴奋性较低。我们认为，在某种程度上，这些差异是由于 VH 的网络兴奋性高于 DH 造成的。此外，它们可能反映了为 DH 和 VH 的局部电路提供突触可塑性所需的最佳能力的专门化，并且还可能表明 VH 可能是 SPW-Rs 起始的有利位点。 (C) 2017 年国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
Functions of the hippocampus are segregated along its long axis and emerging evidence shows that the local circuitry Is specialized accordingly. Sharp waves (SPWs) and ripples are a basic hippocampal network activity implicated in memory processing. Using recordings from the CA1 field of both dorsal (DH) and ventral (VH) rat hippocampal slices we found that SPWs are larger, shorter and occur much more frequently in the VH than in the DH. Clusters of SPWs (i.e. multiple consecutive events grouped in sequences that depend on NMDA receptors) occur with higher probability in the VH and the frequency of occurrence of consecutive intra-cluster events is higher in the VH (similar to 10 Hz) than in the DH (similar to 5 Hz). The ripple oscillation displays higher amplitude and frequency in the VH than in DH and the associated multiunit firing peaks at a later phase of the ripple waves in the VH than in the DH. Isolated unit complex spike bursts display a significantly lower number of spikes and longer inter-spike intervals in the VH than in the DH suggesting that the synaptically driven neuronal excitability is lower in the VH. We propose that to some extent these differences result from the relatively higher network excitability of the VH compared with DH. Furthermore, they might reflect specializations that provide the local circuitries of the DH and VH with the required optimal ability for synaptic plasticity and might also suggest that the VH could be a favored site of SPW-Rs initiation. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.